Isonicotinic acid derivative and its preparation method and use

A derivative, isonicotinic acid technology, applied in the field of isonicotinic acid amide derivatives and their preparation, isonicotinic acid derivatives, isonicotinic acid ester derivatives, can solve the problem of affecting physiological functions, cancer cell proliferation and recurrence, Injury to normal cells and other problems, to achieve a broad-spectrum anti-cancer effect
CN109942566BActive Publication Date: 2021-07-23XIAMEN INST OF RARE EARTH MATERIALS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIAMEN INST OF RARE EARTH MATERIALS
Publication Date
2021-07-23

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Abstract

The invention belongs to the field of medicinal chemistry and relates to a class of isonicotinic acid derivatives with novel structures and their preparation methods and uses. The present invention mainly relates to isonicotinic acid derivatives, stereoisomers, racemates, tautomers, or pharmaceutically acceptable salts thereof represented by formula (I), their preparation methods, and their use in the preparation of anticancer drugs. Uses in medicines. In formula (I): Z is selected from O, S, NR 3 , where R 3 is hydrogen or C 1 ~C 6 Alkyl; R 1 Selected from C 1 ~C 6 Alkyl, C 1 ~C 6 Alkoxy, haloC 1 ~C 6 Alkyl, aryl, aryloxy, heteroaryl, heteroaryloxy, heterocyclyl, heterocyclyloxy, halogen; R 2 Selected from halogen, cyano, nitro, C 1 ~C 6 Alkyl, C 1 ~C 6 Alkoxy or haloC 1 ~C 6 Alkyl; m is an integer from 0-4; n is an integer from 0-5; provided that Z is selected from NR 3 , when m is 0 and n is 1, R 2 Not halogenated.
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Description

technical field

[0001] The invention belongs to the field of medicinal chemistry and relates to a class of isonicotinic acid derivatives with novel structures, in particular to isonicotinic acid ester derivatives and isonicotinic acid amide derivatives containing isoxazole heterocycles and their preparation methods and applications. Background technique

[0002] Most cancers are found in the middle to advanced stages, and the overall response to treatment is poor. Cancer has posed a huge threat to human existence.

[0003] Treatment methods for cancer include surgery, radiation therapy, and chemotherapy. Treatment with surgery sometimes fails to eradicate cancer cells, allowing the cancer to spread and recur. In addition, surgical treatment may lead to irreversible serious consequences, such as cervical cancer and bladder cancer surgery may lead to infertility and sexual dysfunction, etc.; radiation therapy for cancer will damage normal cells; therefore drug treatment is a...

Claims

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