End point judgment method for percolation process of caulis sinomenii

A technology of percolation and rhizome, which is applied in the field of process analysis of traditional Chinese medicine production, can solve problems such as judging the end point of unrefined rhizome, achieve the effect of improving quality control level and saving manpower and material costs

Inactive Publication Date: 2019-07-05
HUNAN ZHENGQING PHARM GRP CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no method for judging the end point of the pe

Method used

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  • End point judgment method for percolation process of caulis sinomenii
  • End point judgment method for percolation process of caulis sinomenii
  • End point judgment method for percolation process of caulis sinomenii

Examples

Experimental program
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Effect test

Embodiment 1

[0034] 1. Collection of spectral information: Weigh 100g of Caulis chinensis medicinal material, soak it with 0.3mol / mL hydrochloric acid solution for 12h and start percolation, control the speed of percolation liquid by peristaltic pump to be 4ml / min, control the liquid addition (percolation The solvent is 0.3mol / L hydrochloric acid solution) and the speed is 4mL / min. The percolation process lasts for about 8-12 hours, and a total of 5 percolation experiments are carried out. The parameters of the spectral scanning are the integration time 1500ms, the average value is taken after 20 scans of each spectrum, and the spectral polling time is 60s.

[0035] 2. Sample collection: At the beginning of percolation, the concentration of sinomenine hydrochloride is relatively high. At this time, the maximum absorbance of the ultraviolet spectrum is about 1.0, and it remains at a high level within 3 hours, so it is carried out 1 hour after the percolation starts. Sampling, once every 20 ...

Embodiment 2

[0049] 1. Collection of spectral information: Weigh 100g of Caulis chinensis medicinal material, soak it with 0.3mol / mL hydrochloric acid solution for 12h and start percolation, control the speed of percolation liquid by peristaltic pump to be 4ml / min, control the liquid addition (percolation The solvent is 0.3mol / L hydrochloric acid solution) and the speed is 4mL / min. The percolation process lasts for about 8-12 hours, and a total of 5 percolation experiments are carried out. The parameters of spectral scanning are integration time 1500ms, the average value is taken after scanning each spectrum 20 times, and the spectral polling time is 60s;

[0050] 2. Collection of samples: at the beginning of percolation, take samples 1 hour after the start of percolation, and take samples every 20 minutes; After 6 hours, sample every 20 minutes;

[0051] 3. Determination of sinomenine hydrochloride content in the sample: adopt HPLC-UV method to measure the concentration of sinomenine hyd...

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Abstract

The invention discloses an ultraviolet spectrum technique based end point judgment method for the percolation process of caulis sinomenii, and belongs to the technical field of traditional Chinese medicine production process analysis. The method includes the following steps: (1) collecting spectrum information; (2) collection samples; (3) determining sinomenine hydrochloride concentrations in thesamples; (4) performing rejecting and dividing on the samples; (5) establishing a correction module; and (6) applying the model. The real-time determination of the sinomenine hydrochloride concentrations during the percolation process of caulis sinomenii can be realized without sampling and analyzing; bases of timely judging the end point of percolation can be provided; the process monitoring andvisualization of the percolation process can be realized; and foundations can be built for deeply understanding the percolation process and enhancing production quality control levels.

Description

technical field [0001] The invention belongs to the technical field of process analysis in the production process of traditional Chinese medicines, and in particular relates to a method for judging the end point of the percolation process of Tenghinus chinensis based on ultraviolet spectrum technology. Background technique [0002] Qingfengteng is the dry cane of Sinomenium acutum (Thunb.) Rehd.et Wils. and Sinomenium acutum (Thunb.) Rehd.et Wils.var.cinereum Rehd.et Wils. It has the functions of dredging the meridians and diuresis, etc. It is mainly used to treat rheumatism and rheumatoid arthritis, joint swelling, limb pain, numbness and other diseases. It has been more than 1,000 years in traditional Chinese medicine to treat rheumatic diseases with Qingfengteng and its compound internally or externally. [0003] Qingfengteng mainly contains alkaloids, including sinomenine, bisinomenine, magnolanine, and tetrandrine. Among them, sinomenine is the main medicinal ingredie...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/74G01N30/88
CPCG01N30/06G01N30/74G01N30/88
Inventor 李文龙瞿海斌张胜仇萍龙宪军彭祖仁叶丽芝莫贞珍
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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