Application of IGFBP3 to preparation of reagent for treating breast cancer

A technology for breast cancer and other uses, applied in the field of medicine, can solve the problems of poor clinical chemotherapy effects, etc., and achieve the effects of enhancing drug sensitivity, promoting apoptosis, and reducing tumorigenicity

Pending Publication Date: 2019-08-02
南通普惠精准医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, rosiglitazone has completely different effects on tumor cells and macrophages in the microenvironment of breast cancer, and the two effects cancel each other out so that the clinical chemotherapy effect is not good

Method used

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  • Application of IGFBP3 to preparation of reagent for treating breast cancer
  • Application of IGFBP3 to preparation of reagent for treating breast cancer
  • Application of IGFBP3 to preparation of reagent for treating breast cancer

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Embodiment Construction

[0025] The scheme of the present invention will be explained in detail below with reference to the accompanying drawings. Those skilled in the art will understand that the following examples are only used to explain the present invention, and should not be construed as limiting the present invention.

[0026] Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0027] Those skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. Other aspects and advantages of the invention will become apparent from the following detailed description taken in conjunction with the accompanying drawings, in which various features of embodiments of the invention are illustrated by way of example. Indeed, the present invention is in no way limited to the...

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Abstract

The invention provides application of insulin-like growth factor binding protein-3 (IGFBP3) to preparation of a reagent for treating breast cancer. The insulin-like growth factor binding protein-3 caninhibit macrophage from being polarized to M2 type after being induced by a peroxisome proliferator activated receptor gamma agonist and can inhibit the M2 type macrophage from releasing anti-inflammatory factor to act on tumor cells of the breast cancer so as to inhibit the tumor cells from generating drug resistance on the peroxisome proliferator activated receptor gamma agonist. Through combination of the peroxisome proliferator activated receptor gamma agonist and the insulin-like growth factor binding protein-3, the effects of synergistically promoting tumor cell apoptosis, enhancing thedrug sensitivity of the tumor cells and reducing the tumorigenicity of a breast cancer cell line are achieved; furthermore, through combination of the peroxisome proliferator activated receptor gammaagonist and the insulin-like growth factor binding protein-3, toxicity on a subject body is avoided and safety is achieved.

Description

technical field [0001] The present invention relates to the field of medicine, in particular to the use of an insulin-like growth factor binding protein-3 (IGFBP3) in the preparation of a reagent for treating breast cancer. Background technique [0002] Breast cancer is one of the most common malignant tumors among women all over the world. At present, there are various treatment methods for breast cancer, including surgery, radiotherapy, chemotherapy, etc. Chemotherapy is also a common treatment method. Breast cancer is a tumor that is moderately sensitive to chemotherapy, and chemotherapy plays an important role in the treatment of breast cancer, especially for patients whose cancer cells have spread. However, the drug resistance of breast cancer cells during chemotherapy will cause many patients to relapse or metastasize in a short period of time after chemotherapy. [0003] Rosiglitazone, as an agonist of peroxisome proliferator-activated receptor gamma (abbreviated as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K45/06A61K31/4439A61P15/14A61P35/00
CPCA61K38/1754A61K31/4439A61K45/06A61P15/14A61P35/00A61K2300/00
Inventor 王国华王金星高纯一周佳敏狄文军
Owner 南通普惠精准医疗科技有限公司
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