Medicine for improving symptoms of acne rosacea, animal model of medicine and construction method of animal model

Abstract

The invention belongs to the technical field of medicaments for skin diseases, and discloses a medicine for improving symptoms of acne rosacea, an animal model of the medicine and a construction method of the animal model. A BALB / C mouse of 7 weeks old is used, subcutaneous injection of LL37 polypeptide is performed twice each day, injection is performed for 2 days, and acne rosacea skin injury isinduced to make a model of the acne rosacea. As for the animal model, the mouse is subjected to intragastric administration of tranexamic acid 5 days in advance, a medicine control group is subjectedto intragastric administration of a PBS buffer solution, and 6-7 days after the intragastric administration, acne rosacea skin injury is induced. Through the adoption of an LL37 induced mouse model and a HaCaT cell model, the influence of TXA on the acne rosacea and the molecular mechanism of the TXA are assessed; through TXA treatment, the acne rosacea symptoms are obviously improved; and in addition, the TXA reduces the expression level of congenital immunity genes (TLR2, KLK5 and Camp) and neutral granulocyte related genes in acne rosacea sample lesion.

Description

technical field [0001] The invention belongs to the technical field of medicaments for skin diseases, and in particular relates to a medicine for improving symptoms of rosacea, an animal model and a construction method thereof. Background technique [0002] Rosacea is a common chronic facial inflammatory disorder that is generally divided into 4 major subtypes: erythematous vasodilatory rosacea (ETR), papulopustular rosacea (PPR), rosacea (PHR) and ocular (OR) Rosacea. Clinical features of rosacea include facial erythema, papules, pustules, telangiectasia, and recurrent flushing, and although it is not a fatal disease, it can adversely affect the quality of life of patients with rosacea. Additionally, recent studies have linked rosacea to an increased risk of dementia and cancer. These findings suggest that rosacea may be a response to a systemic disease that warrants attention. [0003] According to the diagnosis and treatment guidelines of the National Rosacea Associati...

AI Technical Summary

Problems solved by technology

According to previous research reports, we can only know that tranexamic acid can play a role, but due to the complexity of the etiology, it is not clear which link plays a specific role

[0006] In summary, the problem with the prior art is that tranexamic acid is used as a treatment option for rosacea, but the molecular mechanisms underlying its therapeutic effect are unclear

Because it is a reverse research process, it takes a lot of manpower and material resources to carry out large-scale screening work in the early stage

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