A kind of preparation method and application of low molecular weight dextran iron

Abstract

The invention provides a preparation method and application of iron dextran with a weight average molecular weight between 1500-4000Da. Specifically, maltose and sucrose are used as substrates, and under the action of dextran sucrase, they are complexed with ferric chloride to prepare a low-molecular-weight dextran solution, and the dextran iron solution is used to prepare low-molecular-weight dextran Iron Injection. The present invention replaces the method of conventional macromolecule degradation with the method of small molecule polymerization, prepares iron dextran injection with lower molecular weight, uses cheap maltose and sucrose as substrates, and has low preparation cost; and adjusts the substrate maltose and The proportion of sucrose can be used to prepare dextran iron with different sugar chain lengths; a complexation catalyst is introduced in the iron complexation process to improve the complexation efficiency; the obtained low molecular weight dextran injection has less irritation, good absorption, and iron supplementation effect Excellent and other advantages, it can be used as the preferred iron supplement for pigs, cattle, sheep and other livestock.

Description

technical field [0001] The invention belongs to the field of veterinary iron-supplementing drugs, and in particular relates to a preparation method and application of low-molecular-weight dextran iron. Background technique [0002] Dextran, also known as dextran, refers to a homopolysaccharide composed of glucose as a monosaccharide. The difference in the length of the dextran chain determines its different medicinal value. Long-chain dextran is usually a blood volume expansion drug with a molecular weight of tens of thousands to hundreds of thousands; while short-chain dextran can be complexed with ferric hydroxide , made of iron dextran, that is, iron dextran. [0003] As a veterinary iron supplement preparation, iron dextran is mostly an injection for intramuscular injection, and is mostly used for iron supplementation for piglets or sows. Studies have shown that piglets only have about 50mg of iron in their bodies at birth, and 1mg of iron can be obtained from sow milk...

AI Technical Summary

Problems solved by technology

In order to prepare low-molecular-weight iron dextran and reduce adverse reactions, Chinese patent CN101205256A proposes to directly use dextran 5 (weight-average molecular weight 4500-5500Da) as a substrate for degradation, and the cost of raw materials is high; the degradation of molecular weight adopts the method of acid heating , requires a large amount of alkali to neutralize, which increases the pressure of "three wastes" treatment, and the high temperature and long-term degradation process consumes a lot of energy, which further increases the production cost

Chinese patent CN1041762A proposes the use of alkaline hydrolysis to degrade dextran with a large molecular weight, which requires a large amount of acid to neutralize. It also has the disadvantages of high raw material cost, high pressure for "three wastes" treatment, and high energy consumption costs.

Although the enzymatic hydrolysis method is improved compared to the acid hydrolysis and alkaline hydrolysis methods, the lengths of low molecular weight dextran chains obtained are different, and the yield of the specific molecular weight dextran chains obtained by this method after separation and purification lower production cost

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