Disease and metabolite network construction method based on similarity calculation

A technology of similarity calculation and network construction, applied in biological systems, bioinformatics, informatics, etc., can solve problems such as difficult to analyze disease mechanisms, and achieve the effect of eliminating low efficiency and high cost
CN110349619APending Publication Date: 2019-10-18HARBIN INST OF TECH
3 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HARBIN INST OF TECH
Publication Date
2019-10-18

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a disease and metabolite network construction method based on similarity calculation, and belongs to the field of disease and metabolite similarity network construction. The network construction method comprises the following steps: acquiring information of different diseases and metabolites; obtaining a known metabolite related to the disease; finding out the similarity ofdifferent diseases by using an InfD-isSim method; introducing an MISM method to obtain the similarity of metabolites; establishing a network of metabolite similarity; discovering new disease-metabolite relationship by random walk. By means of the method, more potential metabolites related to diseases can be obtained, and the method has extremely important significance in clinical diagnosis, treatment and development of new targeted drugs; by adopting the method, high cost and low efficiency of biological experiments can be avoided; through the method, the first several candidate metabolites ofa certain disease are determined, and through biological experiment verification, the method is an efficient and money-saving method.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a disease and metabolite network construction method based on similarity calculation, belonging to the field of disease and metabolite similarity. Background technique

[0002] In order to maintain the needs of life, complex and orderly chemical reactions take place in the human body. The whole process is called metabolism. Organisms are dependent on metabolites for their maintenance and growth and reproduction. In terms of how energy is obtained, metabolites are divided into two parts. One is to obtain energy through the catabolism of macromolecules, such as cellular respiration. The other is to obtain energy through cellular synthesis, such as protein and nucleic acid. Once people suffer from diseases, the exchange of matter and energy will be abnormal. A cascade of abnormal metabolites then occurs. Therefore, metabolites can be effective in diagnosing diseases and curing diseases.

[0003] Disease understanding at the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More