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Application of aromatic nitroethylene compound

A technology of compounds and uses, applied in the fields of medicine and biology, can solve the problems of affecting the physiological process of cells, affecting the localization of RXRα transcriptional activity, etc.

Pending Publication Date: 2019-10-29
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Under the action of the ligand, the conformation of the receptor will change, affecting the transcriptional activity of RXRα to form homologous or heterodimers or changing the intracellular location of RXRα, thereby affecting various physiological processes of the cell; finally, the F domain , the function of this region remains to be studied

Method used

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  • Application of aromatic nitroethylene compound
  • Application of aromatic nitroethylene compound
  • Application of aromatic nitroethylene compound

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Embodiment Construction

[0184] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0185] 1. Materials and methods

[0186] 1. Experimental materials

[0187] 1.1 Cell lines, strains and compounds

[0188] 1.1.1 Cell lines

[0189] The African green monkey kidney cell line Cos-7 and the human kidney epithelial cell line HEK293T are from the American Type Culture Collection (ATCC).

[0190] 1.1.2 Cloning the host bacteria

[0191] Escherichia col...

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Abstract

The invention provides an application of an aromatic nitroethylene compound. Specifically, the invention provides the application of a compound as shown in a formula (I) and a stereoisomer or pharmaceutically-acceptable salt thereof in preparation of a medicament for regulating the dimer activity of a nuclear receptor RXR or treating neurodegenerative diseases.

Description

technical field [0001] This application relates to the fields of medicine and biology. Specifically, the present application relates to the use of aromatic nitrovinyl compounds in regulating the activity of RXRα dimer, and the use in the preparation of drugs for treating neurodegenerative diseases (especially Alzheimer's disease). Background technique [0002] 1. Alzheimer's disease [0003] Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized by decreased cognitive and memory abilities. With the development of society and the acceleration of aging, the prevalence of Alzheimer's disease is also gradually increasing. According to statistics, more than 50 million people over the age of 65 worldwide suffer from AD, and the number of patients is expected to increase by 50% by 2020. my country is gradually entering an aging society, and there are about 3 to 4 million AD patients in my country. AD disease affects the life of patients in various aspects, ...

Claims

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Application Information

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IPC IPC(8): A61K31/04A61K31/085A61K31/045A61P25/28C07C205/17C07C205/32
CPCA61K31/04A61K31/085A61K31/045A61P25/28C07C205/17C07C205/32
Inventor 周虎曾志平张晓坤任高昂鲍伟张伟东尚策
Owner XIAMEN UNIV
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