Migraine biomarker and use thereof

A biomarker and migraine technology, applied in the field of biomedicine, can solve the problems that migraine diagnostic methods cannot achieve early warning, and cannot predict the onset and development trend of migraine, so as to achieve comfortable and non-invasive testing and ensure accuracy Effect

Active Publication Date: 2019-11-01
SHENZHEN HUADA GENE INST
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the purpose of the present invention is to provide biomarkers for assessing the risk of migraine or early diagnosis of migraine, as well as a method for diagnosing and assessing the risk

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Migraine biomarker and use thereof
  • Migraine biomarker and use thereof
  • Migraine biomarker and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] 1.1 Sample collection

[0095] Referring to the method described in A metagenome-wide association study of gut microbiota in type2 diabetes (Qin, J. et al. Nature 490, 55-60 (2012)), the feces samples were collected and transported frozen and quickly transferred to -80°C for storage , carry out DNA extraction, and obtain the extracted DNA sample. Stool samples from migraine and non-migraine subjects were obtained from adult twins in the UK, totaling 250 individuals, and then 29 samples with missing phenotypes were discarded from the 250 total samples, according to The remaining 221 samples include 167 healthy samples and 54 migraine samples.

[0096] 1.2 Metagenome sequencing and assembly

[0097]The extracted DNA samples were used to construct a sequencing library, and two-way (Paired-end) metagenomic sequencing (insert fragment 350bp, read length 100bp) was performed on the Illumina HiSeq2000 sequencing platform. Filter the data generated by sequencing (quality-con...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to the field of biomedicines and particularly relates to a migraine biomarker and an application thereof. The provided migraine biomarker comprises at least one selectedfrom the following: bacteroides thetaiotaomicron and/or analogues thereof, faecalibacterium prausnitzii and/or analogues thereof, bacteroides intestinalis and/or analogues thereof and anaeroridus colihominis and/or analogues thereof. The present invention provides the biomarker for early diagnosis of the migraine, and a diagnosis and disease risk assessment method of the migraine, and can solve problems that the existing migraine diagnosis method cannot conduct early warn, cannot predict migraine attack, etc.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to migraine biomarkers and uses thereof. Specifically, the present invention relates to a biomarker for migraine or related diseases, a method for diagnosing or predicting the risk of migraine or related diseases, a kit, and the use of migraine biomarkers in the preparation of the kit. Background technique [0002] Migraine (English: Migraine) is a chronic disease with recurrent mild or severe headaches, usually accompanied by various autonomic nervous system symptoms. Migraine is usually localized, recurrent, and self-limited severe headache with associated symptoms of the autonomic nervous system. 15-30% of people with a history of migraine have symptoms of aura, and those who have aura of migraine often have symptoms without aura. The severity of pain, duration and frequency of headaches vary from person to person. A migraine that lasts longer than 72 hours is called status migraine...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12Q1/6883C12Q1/689
CPCC12Q1/6883C12Q1/689C12Q2600/136
Inventor 郭锐进王奇贾慧珏鞠艳梅
Owner SHENZHEN HUADA GENE INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap