Oral solution of colchicine and prescription composition of oral solution
A technology for colchicine and oral solution is applied in the field of colchicine oral solution and preparation thereof, and can solve problems such as inability to sterilize and filter
Active Publication Date: 2019-11-15
HANGZHOU BIO SINCERITY PHARMA TECH CO LTD
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- Abstract
- Description
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- Application Information
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Problems solved by technology
[0008] Another object of the present invention is to solve the problem of inability to sterilize and filter in the production process of the prior art
Method used
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Embodiment 1
[0025] colchicine 0.005％ Hydroxypropylmethylcellulose 2％ Methylparaben 0.18％ Propylparaben 0.02％ Propylene Glycol 10％ Anhydrous citric acid 0.2％ Disodium hydrogen phosphate dodecahydrate 1.6％ Sucralose 0.15％ temptation red pigment 0.01％ strawberry flavor 0.15％
Embodiment 2
[0027]
[0028]
Embodiment 3
[0030] colchicine 0.012％ Hydroxypropylmethylcellulose 0.35％ Methylparaben 0.18％ Propylparaben 0.02％ Propylene Glycol 10％ Anhydrous citric acid 0.2％ Disodium hydrogen phosphate dodecahydrate 1.6％ Sucralose 0.15％ temptation red pigment 0.01％ strawberry flavor 0.15％
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Abstract
The invention particularly relates to an oral solution of colchicine and a prescription composition of the oral solution. The oral solution contains: colchicine, a thickener, a pH adjuster, a bacteriostatic agent, a solvent, a flavoring agent, a pigment, an essence and water. The weight percentage of each component to the total volume of the solution (w / v%) is: colchicine 0.005% to 0.02%, thickener 0.1% to 2%, pH adjuster 0.1% to 2%, bacteriostatic agent 0.02% to 0.2%, solvent 2% to 10%, flavoring agent 0.1% to 0.2%, pigment 0.005% to 0.02%, and essence 0.01% to 0.2%. The oral solution of colchicine provided by the invention solves the problem of sterilization filtration in the production process while ensuring the stability of colchicine.
Description
technical field [0001] The invention provides a colchicine oral solution and a preparation method thereof Background technique: [0002] Colchicine, an alkaloid, was originally extracted from the lily plant colchicine, hence the name, also known as colchicine. Pure colchicine is in the form of yellow needle-like crystals with a melting point of 157°C. Soluble in water, ethanol and chloroform. Bitter, poisonous. Colchicine can inhibit mitosis, destroy the spindle, and make chromosomes stagnate in metaphase. This abnormal division caused by colchicine is called colchicine mitosis. In such mitosis, although the chromosomes split longitudinally, the cell does not divide and cannot form two daughter cells, thus doubling the chromosomes. Since American scholar Blakesley (A.F.Blakeslee) etc. succeeded in doubling the chromosome number of Datura and other plants with colchicine in 1937, colchicine has been widely used in cytology, genetics research and plant breeding. . [00...
Claims
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IPC IPC(8): A61K9/08A61K47/38A61K47/14A61K31/165A61P29/00A61P19/02A61P19/06
CPCA61K9/0095A61K31/165A61K47/14A61K47/38A61P19/02A61P19/06A61P29/00
Inventor 金勇彪周娜楼金芳
Owner HANGZHOU BIO SINCERITY PHARMA TECH CO LTD