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Spray drying method for Chinese traditional medicine formula granules

A technology of traditional Chinese medicine formula granules and drying method, which is applied in the direction of medical formula, medical preparations containing active ingredients, plant raw materials, etc., and can solve the problems of easy sticking to the wall, increased dosage of patients, and large amount of excipients added

Inactive Publication Date: 2019-11-15
BEIJING INCREASEPHARM CORP LTD
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AI Technical Summary

Problems solved by technology

However, the water extract of traditional Chinese medicine contains sugars, mucus, resins and other components, and it is easy to stick to the wall during spray drying. During the production process of traditional Chinese medicine formula granules, in order to prevent the powder from sticking to the wall during the spray drying stage and affect production, it is necessary to add A large number of excipients are used to overcome the problem. Although this method of adding a large amount of excipients solves the process problem, for traditional Chinese medicine formula granules, it will lead to excessive addition of excipients, and the finished product will not achieve the purpose of concentration. The dosage is greatly increased, which does not conform to the process design principles of traditional Chinese medicine formula granules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take the concentrated patchouli extract with a relative density of 1.05 (60°C), then add 2% beta-cyclodextrin, mix well, filter, and atomize at an inlet air temperature of 175°C and an outlet air temperature of 85°C Spray drying was carried out under the condition of the rotating speed of the device at 50 Hz, and the dry paste powder was collected.

[0016] Spray drying: Slightly sticky to the wall, the fluidity of the dry paste powder is average, a small amount of dry paste powder can be collected, and the yield of the dry paste powder is 80.2%.

Embodiment 2

[0018] Take the concentrated patchouli extract with a relative density of 1.05 (60°C), then add 4% beta-cyclodextrin, mix well, filter, and atomize at an inlet air temperature of 175°C and an outlet air temperature of 85°C Spray drying was carried out under the condition of the rotating speed of the device at 50 Hz, and the dry paste powder was collected.

[0019] Spray drying condition: non-stick to wall, good fluidity of dry paste powder, loose dry paste powder can be collected, and the yield of dry paste powder is 95.4%.

Embodiment 3

[0021] Take the concentrated Patchouli extract with a relative density of 1.05 (60°C), then add 5% beta-cyclodextrin, mix well, filter, and atomize at an inlet air temperature of 175°C and an outlet air temperature of 85°C Spray drying was carried out under the condition of the rotating speed of the device at 50 Hz, and the dry paste powder was collected.

[0022] Spray drying conditions: non-stick to the wall, good fluidity of dry paste powder, loose dry paste powder can be collected, and the yield of dry paste powder is 95.6%.

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Abstract

The invention relates to the technical field of production of Chinese traditional medicine formula granules, in particular to an improved spray drying process for the Chinese traditional medicine formula granules. By adopting the spray drying method, especially using specific auxiliary materials, the use number of the auxiliary materials in the formula granules can be controlled to be in the minimum range, the dosage of a patient is reduced, the wall attachment phenomenon in the spray drying process can also be greatly avoided, and material consumption in the spray drying process is reduced, which is quite beneficial for industrial production.

Description

technical field [0001] The invention relates to the technical field of production of traditional Chinese medicine formula granules, in particular to an improved spray-drying method of traditional Chinese medicine formula granules, which belongs to the technical field of traditional Chinese medicine production. Background technique [0002] Traditional Chinese medicine formula granules are granules made by extracting and concentrating single-flavored Chinese medicine decoction pieces, and are used for clinical formulas of traditional Chinese medicine. It used to be called single-flavor Chinese medicine concentrated granules in China, and its trade name and folk appellation also include decoction-free Chinese medicine slices, new slices, refined slices, beverage-type slices, scientific Chinese medicine, etc. [0003] The drying process is an important link in the preparation of traditional Chinese medicine formula granules. There are many ways to dry traditional Chinese medici...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K36/532A61K36/71A61K36/65A61K9/14A61K47/40
CPCA61K9/146A61K36/484A61K36/532A61K36/65A61K36/71A61K2236/51
Inventor 张保献李艳英李欣欣
Owner BEIJING INCREASEPHARM CORP LTD
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