Liquid chromatography-mass spectrometry combined analysis method and interface device thereof

A technology of liquid chromatography mass spectrometry and analysis method, which is applied in the field of analysis methods combined with liquid chromatography mass spectrometry and an interface device thereof, can solve the problems of affecting signal intensity, reducing signal intensity, breaking the dynamic balance of mass spectrometry, etc., so as to improve ionization The effect of improving efficiency and signal strength
CN110455972AActive Publication Date: 2019-11-15哈尔滨阿斯顿仪器有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
哈尔滨阿斯顿仪器有限公司
Publication Date
2019-11-15

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Abstract

The invention relates to a liquid chromatography-mass spectrometry combined analysis method and an interface device thereof. A mass spectrometer performs analysis and obtains an analysis map through the following steps: installing a solid probe; setting a shunt piece; installing a sample tube; turning on a liquid chromatography system and the mass spectrometer and applying a high voltage to the solid probe; then injecting a sample solution to perform an electrospray process; and adjusting a position of the solid probe to obtain a maximum signal of the mass spectrometer. According to the invention, the solid probe with a shunt piece is used as a liquid chromatography-mass spectrometry combined electrospray ion source interface, and most of the sample effluent of the liquid chromatography system is shunted along the shunt piece and only a small fraction is sprayed. The spray droplet produced by the invention has small diameter and high surface charge density; therefore, the signal intensity of the invention is higher than that of the conventional liquid chromatography-mass spectrometry combined system.
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Description

technical field

[0001] The invention relates to the field of liquid chromatography mass spectrometry analysis, in particular to an analysis method of liquid chromatography mass spectrometry and an interface device thereof. Background technique

[0002] Liquid chromatography (HPLC) methods can separate a variety of compounds, especially for thermally unstable and non-volatile samples that cannot be handled by gas chromatography. Electrospray ionization mass spectrometry (ESI-MS), as one of the most widely used mass spectrometry techniques, can analyze various types of compounds, especially the analysis of thermally unstable and non-volatile biomacromolecules. The ion source of electrospray mass spectrometry adopts a capillary tube with high voltage applied. The sample solution carried in the capillary tube forms a spray at the capillary mouth under the action of high voltage, and finally the formed ions enter the mass spectrometer to be detected. Therefore, the electrospray ...

Claims

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