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Ultra-sensitive electrochemical sensor for detecting sulfathiazole and a detection method thereof

A sulfathiazole and sensitive detection technology, applied in the direction of electrochemical variables of materials, can solve the problems of long analysis time, high price, complex sample pretreatment technology, etc., and achieve the effect of short analysis time, low cost and good electrical conductivity

Active Publication Date: 2019-11-26
SHANDONG AGRICULTURAL UNIVERSITY
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Problems solved by technology

However, the equipment used in the above detection methods is expensive, the analysis time is long, and complex sample pretreatment technology is required; and the sensitivity of the above detection methods has just reached the relevant requirements, and there is no ultra-sensitive detection in the prior art. Therefore, it is of great significance to develop a fast, accurate and sensitive detection method for sulfathiazole

Method used

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  • Ultra-sensitive electrochemical sensor for detecting sulfathiazole and a detection method thereof
  • Ultra-sensitive electrochemical sensor for detecting sulfathiazole and a detection method thereof

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Embodiment 1

[0059] 1. Modification of electrochemical sensor electrodes:

[0060] 8 μL of Au@COF composite material solution with a concentration of 2.0 mg / mL was drop-coated on the surface of the bare glassy carbon electrode and dried at room temperature. The modified Au@COF / GCE electrode was obtained; 10 μL of CuS dispersion solution with a concentration of 1.5mg / mL was drop-coated on the surface of the Au@COF / GCE electrode, and dried to obtain the modified CuS / Au@COF / GCE electrode; The CuS / Au@COF / GCE electrode was immersed in an acetonitrile solution containing 5 mM sulfathiazole, 0.1 M pyrrole, and 0.1 M tetrabutylammonium perchlorate for electrochemical polymerization. Use cyclic voltammetry to scan 5 circles at a rate of 100mV / s within the potential range of -0.6V-+1.2V. Then immerse the electrode in a NaOH solution with a concentration of 1.0mol / L and use cyclic voltammetry to scan 15 circles at a rate of 50mV / s in the potential range of -0.6V-+1.2V to obtain the Au@COF composite,...

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Abstract

The invention discloses an ultra-sensitive electrochemical sensor for detecting sulfathiazole and a detection method thereof. The electrochemical sensor uses an Au@COF composite material, a CuS signalprobe and a MIP common modified electrode as working electrodes. The Au@COF composite material has the advantages of large specific surface area and good electrical conductivity, which can significantly increase the strength of a current signal. CuS is used as a signal probe, which can improve the sensitivity of the sensor. The MIP modified electrode can realize specific sulfathiazole identification of the electrochemical sensor. According to the invention, the minimum detection limits of sulfathiazole of the electrochemical sensor are 0.02 micron / kg, which can meet detection needs; the pre-treatment time and analysis time are shortened by about 85 minutes and 9 minutes respectively compared with a traditional detection method; and the electrochemical sensor is suitable for rapid detection of sulfathiazole.

Description

technical field [0001] The invention relates to a detection method of sulfathiazole, in particular to an electrochemical sensor for supersensitive detection of sulfathiazole and a detection method thereof, belonging to the technical field of food safety detection. Background technique [0002] Sulfathiazole is a commonly used sulfonamide anti-infective drug in clinical practice in my country. Inhibits bacterial growth and reproduction by interfering with the metabolism of folic acid. Because of its high efficiency, low cost, and stable properties, it is widely used in the treatment of various animal bacterial infections. Also because of its wide application, the phenomenon of abuse is becoming more and more serious. Sulfathiazole residues in animal foods will accumulate in the human body through the food chain, thereby reducing the body's physical function, causing stomach discomfort, anemia, and kidney disease and blood disease. disease, and is potentially toxic and carci...

Claims

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Application Information

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IPC IPC(8): G01N27/30G01N27/26
CPCG01N27/26G01N27/30
Inventor 徐志祥孙玉奉张鸿雁李国琛辛军红
Owner SHANDONG AGRICULTURAL UNIVERSITY
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