Establishing method of spleen deficiency damp obstruction type simple obesity animal model
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A technology for simple obesity and spleen deficiency and damp resistance, applied in the medical field, can solve problems such as difficulty in eliminating abdominal distension
Active Publication Date: 2019-12-13
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Many patients often complain that they feel abdominal distension and discomfort after eating a little food, and it is difficult to eliminate this abdominal distension even with moderate exercise
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Embodiment 1
[0040] This embodiment provides a method for establishing a simple obesity animal model of spleen deficiency and dampness type, which includes the following steps:
[0041]S1: Purchase 70 male SD strain rats of healthy and clean grade with a body weight of 200-220g, divide the purchased 70 healthy rats into 7 groups, and live in a cage with a length of 2m, width of 1m and height of 1m for every 10 rats, and randomly select The six groups are the model group, and one group is the normal control group. For the normal control group, they are fed with common feed without restriction of normal diet and drinking water. The model group is modeled according to the following steps S2-S4, unless otherwise specified below, it is the model group.
[0042] S2: Adaptive feeding, including:
[0043] S21: In the first week: for the first three days, the mice were first fed with common feed: high-fat feed at a mass ratio of 3:1, adding new feed at a fixed time every day and weighing the remai...
Embodiment 2
[0093] The difference between this example and Example 1 is that in step S1, 40 healthy and clean male SD strain rats with a body weight of 180-200 g were purchased and divided into 5 groups with 8 rats in each group, which were respectively the normal control group and the model rats. group, high-dose Chinese medicine group, medium-dose Chinese medicine group, and low-dose Chinese medicine group.
[0094] The traditional Chinese medicine is Guben Qushi Huaphlegm and Zhizhi Formula, and the composition of each part is expressed in parts by weight as 12 parts of Poria cocos, 12 parts of Atractylodes macrocephala, 9 parts of Codonopsis pilosula, 12 parts of Chinese yam, 9 parts of fried coix seed, and 12 parts of Citrus aurantii. 12 parts of tangerine peel, 12 parts of salvia miltiorrhiza, 9 parts of hawthorn, 6 parts of amomum, 1 part of stevia, 9 parts of lotus leaf, 6 parts of green dill flower, 9 parts of red yeast rice, 9 parts of cassia seed and 9 parts of alisma. The conv...
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Abstract
The invention relates to an establishing method of a spleen deficiency damp obstruction type simple obesity animal model. The method includes the steps of S1, purchasing healthy and clean male SD-strain rats with weights of 180-220 g; S2, conducting adaptive feeding, wherein the purchased healthy rates are fed by a mixture of an ordinary feed and a high-fat feed for 1 week, the food ration per gram of weight is calculated, and the rats are adaptively fed with a high-fat feed for 1 week on the basis of the number larger than or equal to the food ration per each gram of weight; S3, establishinga spleen deficiency damp obstruction type obesity model, wherein after the selected rats are fed for 8-11 weeks according to a certain mode in the environment with the temperature of 22-28 DEG C and the air humidity of 40-50%, the weight of each rat is measured, and the rats with the weights larger than or equal to 500 g are selected; S4, scoring and judging the selected rats according to certainindexes, and selecting the successfully-established spleen deficiency damp obstruction type simple obesity animal model. By means of the modeling method, the spleen deficiency damp obstruction type simple obesity animal model similar to human symptoms is obtained for reference for treating spleen deficiency damp obstruction type simple obesity.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a method for establishing a simple obesity animal model of spleen deficiency and dampness type, and establishes a simple obesity animal model of spleen deficiency and dampness type for medical research. Background technique [0002] Simple obesity is the most common nutritional disorder disease in modern society. It refers to the disease that has no clear endocrine or genetic reasons, and the excessive accumulation of adipose tissue in the body due to caloric intake exceeds consumption, resulting in abnormal body weight. Secondary obesity. The incidence of simple obesity in the world is increasing year by year. It is closely related to the incidence of hypertension, diabetes, dyslipidemia, cardiovascular and cerebrovascular diseases, which seriously endangers human health and has become a global public health issue. question. After 40 years of BMI surveys in 186 countries, som...
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