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Non-exposed intratracheal instillation method for rats

A technique of instillation and trachea, which is applied in the field of experimental research on respiratory diseases, can solve the problems of low success rate of intubation, difficulty in judging the success of tracheal intubation, difficulty of tracheal intubation, etc., achieving good reliability and high success rate , the effect of simple method

Inactive Publication Date: 2019-12-13
NANHUA UNIV
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Problems solved by technology

It solves the problems of difficult tracheal intubation, low intubation success rate and difficulty in judging whether tracheal intubation is successful in the existing rat tracheal instillation operation

Method used

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  • Non-exposed intratracheal instillation method for rats
  • Non-exposed intratracheal instillation method for rats

Examples

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Embodiment 1

[0031] Rat non-exposed tracheal instillation method, the steps are as follows:

[0032] S01, making the cannula: select a No. 9 disposable sterile injection needle, grind the tip of the No. 9 disposable sterile injection needle until it is round and blunt, and bend it at a distance of 10mm from the blunt end of the No. 9 disposable sterile injection needle, and the bending angle a is 14-16°, which is named rat tracheal intubation (see figure 1 ), one end of the rat tracheal intubation tube 1 is a liquid outlet 11, and the other end is a syringe connection end 12.

[0033] S02, anesthesia: select adult rats, anesthetize them with ether, and proceed to the next step if their muscles relax, eyelid closing reflex disappears, skin is pinched with toothed forceps or toes do not contract.

[0034] S03, fixation: the anesthetized rat was placed on the operating table in a supine position, and its upper incisors were fixed on the operating table with rubber bands and limbs with cotton...

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Abstract

The invention discloses a non-exposed intratracheal instillation method for rats. The method comprises the following steps: 1, manufacturing of an intubation tube; 2, anesthetization; 3, fixing; 4, tracheal intubation; 5, instilling; 6, gas injection; and 7, resuscitation. The non-exposed intratracheal instillation method for rats has the tracheal intubation operation simple and easy to operate, and is high in success rate, low in requirement for instruments and equipment, free of expensive equipment, small in injury probability of a tested rat in the tracheal intubation and instillation process and capable of being widely applied to respiratory tract administration or contamination tests and establishment of various disease models.

Description

technical field [0001] The invention relates to the field of experimental research on respiratory system diseases, in particular to a non-exposed trachea instillation method for rats. Background technique [0002] Rat tracheal instillation technique is commonly used in rat trachea administration, rat trachea administration modeling, rat lung function determination and experimental research related to respiratory diseases. Tracheal instillation is required for rat-related model replication and rat lung function testing. The tracheal instillation technique directly affects the success rate of animal model replication and lung function testing, and is critical throughout the experiment. [0003] Tracheal instillation is a method of delivering drugs into the lungs through endotracheal intubation. Compared with endotracheal intubation, it does not need to expose the trachea through surgical incisions and causes less harm to the subject of administration. In larger animals (eg, r...

Claims

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Application Information

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IPC IPC(8): A61D7/00
CPCA61D7/00
Inventor 张朝晖王烨雷媛娣李鹏谭滇湘
Owner NANHUA UNIV
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