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A kind of artificial leather and preparation method thereof

A leather and artificial technology, applied in the field of bionic materials, can solve problems such as easy cracking and structure collapse, and achieve the effects of facilitating repair, shortening process time, and reducing production costs

Active Publication Date: 2021-07-06
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main preparation method of the existing synthetic dermis substitute is the method of freeze-drying-crosslinking treatment. For example, US20160143726 discloses a preparation method of artificial dermis. After solution preparation, freeze-drying, high-temperature treatment, solution crosslinking, finishing Collagen-chondroitin sulfate-tropoelastin dermal matrix is ​​obtained through cleaning and other processes. However, there are defects that it is easy to crack when freeze-dried and the structure is easy to collapse when the solution is cross-linked.

Method used

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  • A kind of artificial leather and preparation method thereof
  • A kind of artificial leather and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0030] The present embodiment provides a kind of artificial dermis, makes through the following steps:

[0031] (1) Prepare the solution of artificial dermis raw materials: get 0.6g collagen and 0.06g chondroitin sulfate and disperse in 100g 0.05M acetic acid solution, disperse at high speed, form 0.66wt% collagen-chondroitin sulfate solution;

[0032] (2) Add 0.05% glutaraldehyde solution to the solution of the artificial leather raw material, stir for 1 hour, and then perform defoaming treatment to obtain a composite solution;

[0033] (3) pour the composite liquid into the mould, spray a layer of 0.2mol / L sodium chloride solution on the mold filled with the composite liquid, and then carry out two freeze-thaw treatments. The specific process is: transfer the mold to- In the ultra-low temperature refrigerator at 60°C, after freezing for the first time for 2 hours, take it out and perform the first thawing at room temperature. The first thawing time is 10 minutes. Freeze for...

Embodiment 4

[0043] The present embodiment provides a kind of artificial dermis, makes through the following steps:

[0044] (1) Prepare the solution of artificial dermis raw material: get 0.6g collagen and 0.1g chitosan and disperse in 100mL 0.05M acetic acid solution, form 0.7wt% collagen-chitosan solution;

[0045] (2) adding 0.01% glutaraldehyde solution to the solution of the artificial leather raw material, stirring for 2 hours, and then defoaming to obtain a composite solution;

[0046] (3) Pour the composite liquid into the mold, spray a layer of 0.8mol / L sodium chloride solution on the mold filled with the composite liquid, and then perform freeze-thaw treatment. The specific process is: transfer the mold to -60°C In the ultra-low temperature refrigerator, after freezing for 1 hour, take it out and perform the first thawing at room temperature. The first thawing time is 10 minutes. At this time, the surface crystals formed by the sodium chloride solution have not yet melted;

[0...

Embodiment 5

[0050] The present embodiment provides a kind of artificial dermis, makes through the following steps:

[0051] (1) Prepare the solution of artificial dermis raw materials: take collagen and disperse it in water to form 0.35wt% collagen solution;

[0052] (2) Add 0.10% glutaraldehyde solution to the solution of the artificial leather raw material, stir for 2 hours, and then perform defoaming treatment to obtain a composite solution;

[0053] (3) Pour the composite solution into the mold, spray a layer of 0.4mol / L potassium chloride solution on the mold filled with the composite solution, and then perform freeze-thaw treatment. The specific process is: transfer the mold to -60°C In the ultra-low temperature refrigerator, after freezing for 1 hour, take it out and perform the first thawing at room temperature. The first thawing time is 10 minutes. At this time, the surface crystals formed by the sodium chloride solution have not yet melted;

[0054] Then put it back into the ul...

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Abstract

The invention discloses an artificial dermis and a preparation method thereof. The preparation method of the artificial dermis comprises the following steps: (1) preparing a solution of artificial dermis raw materials, the artificial dermis raw materials containing collagen; Add a cross-linking agent to the solution of the raw leather material, and mix to obtain a composite solution; (3) spray a salt solution on the surface of the composite solution, and then perform a freeze-thaw treatment, and the freeze-thaw treatment includes freezing and first thawing; During the thawing process, the salt solution is frozen to form surface crystals, and then the surface crystals formed by the salt solution are in an unthawed state through the first thawing; (4) Freezing and second thawing, after the second thawing Wash until all frozen items are completely thawed. The interior and surface of the artificial dermis obtained by the preparation method of the present invention have a through hole structure, which is beneficial to skin repair.

Description

technical field [0001] The invention relates to the technical field of bionic materials, in particular to an artificial leather and a preparation method thereof. Background technique [0002] Once the skin, especially the dermis, is damaged, the function of the skin will be damaged, which may threaten human health in severe cases. The traditional treatment method is autologous skin graft or skin flap transplantation. However, these treatment methods belong to the practice of tearing down the east wall to make up for the west wall, which will cause secondary trauma to the human body. For patients with large-scale trauma, the skin source is often insufficient, and artificial Leather design can solve this problem. Artificial leather refers to artificial leather substitutes, including natural artificial leather and artificial synthetic artificial leather. Among them, artificial synthetic leather is made of collagen, chitosan and hyaluronic acid as the main raw materials. Synt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/10
CPCA61F2/105A61F2240/001
Inventor 许孟强郭远军谭荣伟佘振定王丹妍刘曦陈滢滢梁嘉美李丽花张文强
Owner SHENZHEN QIKANG MEDICAL DEVICES