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Preparation of boswellic acid and derivatives and application thereof in resisting glioma

A technology for glioma and boswellic acid, which can be used in antitumor drugs, medical preparations containing active ingredients, drug combinations, etc., and can solve problems such as low clinical efficacy

Pending Publication Date: 2019-12-17
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been widely used in the chemotherapy of central nervous system tumors, especially malignant glioma, and has become a "milestone" in the progress of glioma chemotherapy. It has become the first-line chemotherapy drug for clinical treatment of malignant glioma. TMZ has obvious drug resistance, so the clinical effective rate of TMZ is less than 45%

Method used

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  • Preparation of boswellic acid and derivatives and application thereof in resisting glioma
  • Preparation of boswellic acid and derivatives and application thereof in resisting glioma
  • Preparation of boswellic acid and derivatives and application thereof in resisting glioma

Examples

Experimental program
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Effect test

Embodiment 1

[0017] 1. Extraction, separation and purification of 11-carbonyl-β-acetylboswellic acid:

[0018] Take 2 kg of frankincense coarse powder and heat reflux with 5 times the amount of 95% ethanol for 2 hours, recover the solvent in the extract under reduced pressure, and obtain the alcohol extraction extract. Dissolve the extract, mix the sample with 200-300 mesh silica gel, and segment through a silica gel decompression column. The corresponding parts obtained are subjected to repeated silica gel column chromatography, eluted with petroleum ether: ether 3:1, and a total of 6.85 white crystals are precipitated. g, detected by HPLC as 11-carbonyl-β-acetylboswellic acid with a purity of 99%. The mother liquor was reversed phase C 18 Column chromatography separation, gradient elution with 80%-100% methanol-water solution, TLC monitoring, similar components were combined, and the obtained subcomponents were subjected to repeated silica gel column chromatography, and white was eluted...

Embodiment 2

[0023] 1. Extraction, separation and purification of 11-carbonyl-β-acetylboswellic acid:

[0024] Take 1.5 kg of frankincense coarse powder and heat reflux with 5 times the amount of 95% ethanol for 2.5 hours, and recover the solvent in the extract under reduced pressure to obtain 1.0 kg of alcohol-extracted extract. Dissolve the extract, mix the sample with 200-300 mesh silica gel, and segment through a silica gel decompression column. The obtained parts are subjected to repeated silica gel column chromatography, eluted with petroleum ether: ether 3:1, and a total of 5.93 g of white crystals are precipitated , with a purity of 99%, detected as 11-carbonyl-β-acetylboswellic acid by HPLC.

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Abstract

The invention discloses a method for extracting a mass of 11-carbonyl-beta-acetylboswellic acid (AKBA) from frankincense and application thereof in resisting glioma and breast cancer. It is found that11-carbonyl-beta-acetylboswellic acid has a significant inhibitory effect on the growth of human glioma cells A172 and human breast cancer cell line MDA-MB-231, and can be used as a medicine for treatment of glioma and breast cancer.

Description

technical field [0001] The invention relates to a method for extracting, separating and purifying 11-carbonyl-β-acetylboswellic acid from frankincense and its application in resisting glioma and human breast cancer. Background technique [0002] In China, tumor is the first cause of disease death, and the morbidity and mortality are still rising, which has become a serious public health problem. my country has a huge population base. At present, 22% of new cancer cases and 27% of cancer deaths in the world occur in China. In 2015, China is expected to have 4.292 million new cancer cases and 2.814 million deaths; among them, brain and central nervous system tumors have 101,600 new cases and 61,000 deaths. [0003] Glioma is the type with the highest incidence rate among brain tumors; because of its fast growth and short course of disease, the biological characteristics of glioma are extremely aggressive, and there is no obvious boundary with the surrounding normal brain tiss...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P35/00C07J63/00
CPCA61K31/56A61P35/00C07J63/008
Inventor 王金华吉腾飞杜冠华王佳佳
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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