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A medical periosteum support carrying ion and geometric pattern signals and its construction method

A technology of geometric patterns and construction methods, applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problems of inability to meet the clinical needs of bone injury repair, single function of artificial periosteum, unsatisfactory treatment effect, etc., and achieve the improvement of biology and mechanics. Compatibility, good histocompatibility, biodegradability Effect of histocompatibility

Active Publication Date: 2021-07-23
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In order to solve the technical problems that the existing artificial periosteum has a single design function, cannot meet the needs of clinical bone injury repair, and leads to unsatisfactory treatment effects, the purpose of the present invention is to provide a novel design and process that uses ion and geometric pattern signals to jointly construct A simple and operable medical periosteum scaffold, which can realize the construction of a bionic natural periosteum scaffold by combining ionic and geometric pattern signals, obtain mechanics similar to natural periosteum, induce bone component regeneration and structural reconstruction, induce angiogenesis and inhibit bacteria The function of proliferation helps the bone tissue repair and functional stability of the injured part to rebuild

Method used

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  • A medical periosteum support carrying ion and geometric pattern signals and its construction method
  • A medical periosteum support carrying ion and geometric pattern signals and its construction method
  • A medical periosteum support carrying ion and geometric pattern signals and its construction method

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Experimental program
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Effect test

Embodiment 1

[0049] A biomimetic medical periosteum scaffold constructed synergistically with ion and geometric pattern signals is prepared by the following method:

[0050] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0051] According to the design, 1g of PCL was weighed and added to the experimental bottle, 3.5ml of dichloromethane and 1.5ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluidic direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle inner diameter 0.52 mm direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, direct writing Writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a straight line grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the mi...

Embodiment 2

[0059] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0060] According to the design, 1.25g of PCL was weighed and added to the experimental bottle, 4.0ml of dichloromethane and 1.0ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluid direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle inner diameter 0.52 mm, direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, Direct writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a 30° zigzag grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the microinjection pump, and the direct-writing fibers support the skeleton.

[0061] The second step: preparation of inner surface fiber layer (geometric pattern signal...

Embodiment 3

[0068] The first step: the preparation of the intermediate fiber layer (fiber support skeleton)

[0069] According to the design, 0.75g of PCL was weighed and added to the experimental bottle, 4.5ml of dichloromethane and 0.5ml of ethanol were added, and the PCL direct writing solution was formed after fully dissolving for 6 hours. Set the near-field electrofluid direct writing parameters as solution flow rate 100 μl / min, needle tip-collecting plate distance 2 mm, voltage 4 kV, direct writing needle diameter 0.52 mm, direct writing platform moving speed 1 (vertical and stretching direction) 20 mm / s, direct writing platform Writing platform moving speed 2 (parallel and stretching direction) 60mm / s. Design the direct writing pattern as a 60° zigzag grid pattern (area: 70×70cm 2 ), and add the direct-writing solution into the microinjection pump, and the direct-writing fibers support the skeleton.

[0070] The second step: preparation of inner surface fiber layer (geometric pat...

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Abstract

The invention discloses a medical periosteum support constructed by synergistically using ion and geometric pattern signals and a construction method thereof, comprising: inner surface fiber layer: composed of wavy, oriented and arranged loose porous fibers, which are degradable and stretchable Molecular materials, providing geometric pattern signal delivery for periosteal scaffolds; middle fiber layer: composed of grid-like fibers, which are degradable and stretchable polymer materials, providing mechanical support for periosteal scaffolds; outer surface fiber layer: composed of disordered, The dense composite fiber is composed of degradable polymer materials and ion-doped bioceramic micro-nano particles, which provide ion signal delivery for the periosteum scaffold. The present invention can realize the construction of bionic natural periosteum scaffold by combining ion and geometric pattern signals, and obtain the functions of mechanics similar to natural periosteum, inducing bone component regeneration and structural reconstruction, inducing angiogenesis and inhibiting bacterial proliferation, and helping the damaged bone Tissue repair and reconstruction of functional stability.

Description

technical field [0001] The invention relates to a bionic medical periosteum support and a construction method thereof, in particular to a medical periosteum support which can promote the growth of bone tissue and a construction method thereof which is co-constructed by ion and geometric pattern signals, and belongs to the technical field of biomedical materials. Background technique [0002] Scaffold is an important functional material in the repair of clinical bone tissue injury. However, current scaffold materials lack the ability to guide the formation of new bone components and structures at the site of bone tissue damage. In the human body, the periosteum is a dense tissue that wraps the outer surface of the bone and is mainly composed of an outer collagenous fibrous layer (rich in fibroblasts and microvessels) and an inner layer of osteoblasts (storage for bone growth, healing, and remodeling). Progenitor cells) provide different types of necessary cells for bone tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/46A61L27/50A61L27/54A61L27/56A61L27/58
CPCA61L27/18A61L27/46A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/404A61L2300/412A61L2300/604A61L2430/24C08L77/02
Inventor 王祖勇章万奇吝楠马超
Owner HUNAN UNIV
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