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Composition containing recombinant human fibronectin peptide

A technology of human fibronectin and fibronectin, applied in medical preparations containing active ingredients, drug combinations, peptide/protein components, etc., can solve the problems of difficult wound healing, increased side effects, repeated infections, etc., to promote healing Smooth, repairable, easy-to-absorb effect

Active Publication Date: 2020-01-10
GUANGZHOUJIDABIOLOGICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Especially in the process of chronic wound repair such as diabetic ulcers, due to the existence of biofilm formed by bacteria, repeated infections will occur, and the phenomenon that the wound is difficult to heal for a long time. If the drug dose is increased, side effects will increase, and the clinical drug-resistant bacteria Continuous production also increases the difficulty of treatment

Method used

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  • Composition containing recombinant human fibronectin peptide
  • Composition containing recombinant human fibronectin peptide
  • Composition containing recombinant human fibronectin peptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Preparation of Compositions Containing Fibronectin

[0023] A composition containing fibronectin, the mass concentration of each component is shown in Table 1:

[0024] Table 1

[0025] components mass concentration ratio Fibronectin 40μg / mL Lysozyme 35 μg / mL Arginine / Lysine Peptides 5μg / mL Tripeptide-1 Copper 500μg / mL water 1mL

[0026] Mix all the ingredients of the above formula evenly according to the proportion, and swell or dissolve in water.

Embodiment 2

[0027] Embodiment 2: Preparation of compositions containing rhFnp

[0028] A composition containing rhFnp and lysozyme, the mass concentration of each component is shown in Table 2:

[0029] Table 2

[0030] components mass concentration ratio wxya 40μg / mL Lysozyme 35 μg / mL Arginine / Lysine Peptides 5μg / mL Tripeptide-1 Copper 500μg / mL water 1mL

[0031] Mix all the ingredients of the above formula evenly according to the proportion, and swell or dissolve in water.

Embodiment 3

[0032] Example 3: Preparation of compositions containing rhFnp

[0033] A composition containing rhFnp and lysozyme, the mass concentration of each component is shown in Table 3:

[0034] table 3

[0035] components mass concentration ratio wxya 75μg / mL Lysozyme 35 μg / mL Arginine / Lysine Peptides 5μg / mL Tripeptide-1 Copper 500μg / mL water 1mL

[0036] Mix all the ingredients of the above formula evenly according to the proportion, and swell or dissolve in water.

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PUM

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Abstract

The invention discloses a composition containing a recombinant human fibronectin peptide. The composition is composed of an active substance and an excipient, the active substance includes fibronectin, lysozyme, arginine / lysine polypeptide and tripeptide-1 copper. The weight ratio of the fibronectin to the lysozyme to the arginine / lysine polypeptide to the tripeptide-1 copper is (0.01-10) to (0.01-10) to (0.01-10) to (0.01-10). The composition has remarkable efficacy in promoting wound healing and smoothness, controlling oil and water and the like. The composition can be further prepared intosemi-solid preparations such as lyophilized powder, nano microspheres, nano liposomes, aqueous agents, gels after being compounded with appropriate excipients, and is used as an active additive in thefield of tissue engineering, pharmacy and beauty skin care.

Description

technical field [0001] The present invention relates to the fields of biomedicine and cosmetics, in particular to a composition containing recombinant human fibronectin peptide (rhFnp). Background technique [0002] The main function of the skin is to protect the body from adverse factors in the external environment. Generally speaking, the skin barrier can be divided into broad sense and narrow skin barrier. The skin barrier in a broad sense includes physical barrier, pigment barrier, nerve barrier, and immune barrier; the skin barrier in a narrow sense mainly refers to the physical barrier function of the epidermis, especially the stratum corneum, which is the first natural defense line of our body against the external environment. When the skin is damaged, if it cannot heal in time, a large amount of exudate will appear on the surface of the wound, which will hinder the regeneration of the epidermis and the closure of the wound, thus significantly affecting the progress ...

Claims

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Application Information

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IPC IPC(8): A61K38/47A61K8/64A61K8/65A61K8/66A61L27/22A61L27/24A61L27/54A61P17/02A61P31/02A61P31/04A61Q19/00A61Q19/08A61K38/39A61K38/06A61K38/02
CPCA61K38/06A61K38/39A61K38/47C12Y302/01017A61K38/02A61K8/65A61K8/64A61K8/66A61P17/02A61P31/02A61P31/04A61Q19/008A61Q19/08A61L27/24A61L27/227A61L27/54A61K2800/5922A61K2300/00
Inventor 项琪黄亚东陈颖之薛来武
Owner GUANGZHOUJIDABIOLOGICAL TECH CO LTD
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