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Noise deep-brain-stimulation system based on delayed feedback control

A feedback control and noise technology, applied in the field of biomedical engineering, can solve the problems of increased surgical risk, the need to replace batteries regularly, and high energy consumption of DBS, and achieve the effect of broadening the application range, flexible electrode functions, and easy implementation

Active Publication Date: 2020-01-14
TIANJIN UNIV
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Problems solved by technology

However, DBS has the following disadvantages: on the one hand, applying clinical standard DBS stimulation with pulses of about 130 Hz will cause synchronous discharge of neurons in the basal ganglia of the brain near the same frequency, which may bring other negative effects; on the other hand, The energy consumption of DBS is high, and the battery needs to be replaced regularly, which greatly increases the risk of surgery

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Embodiment Construction

[0017] The technical solution of the present invention will be clearly and completely described and explained below in conjunction with the embodiments and the accompanying drawings, but it is not used as a limitation of the protection scope of the present application.

[0018] The technical solution of the present invention will be clearly and completely described and explained below in conjunction with the embodiments and the accompanying drawings, but it is not used as a limitation of the protection scope of the present application.

[0019] A novel noise deep brain stimulation system (system for short, see Figure 1-2 ), it is characterized in that the system includes a bidirectional electrode 1, a microcontroller 2, a host computer 3, a noise generator 4 and a filter 5;

[0020] There are two bidirectional electrodes 1, and the bidirectional electrodes 11 and 12 are respectively inserted on the STN nuclei in the basal ganglia on the left and right sides of the brain. Acq...

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Abstract

The invention relates to a noise deep-brain-stimulation system based on delayed feedback control. The noise deep-brain-stimulation system based on delayed feedback control is characterized by comprising two bidirectional electrodes, a microcontroller, a host computer, a noise generator and a filter, wherein the two bidirectional electrodes are separately inserted into STN in a left basal nucleus and a right basal nucleus of the brain, the bidirectional electrodes have two properties of acquisition and stimulation, acquisition of local field potentials (LFPs) of the STN of a subthalamic nucleusand application of noise stimulation are achieved, and an acquisition signal is transmitted to the microcontroller; the microcontroller comprises a pre-processing module, an estimation module and a delayed feedback control module; the host computer is used for calculating and displaying a discharge sequence, the LFPs, a discharge rate and power spectral density (PSD) of the nucleuses in the basalnucleuses, a discharge sequence and a reliability index (RI) of a thalamus nucleus and all noise parameters, and transmitting the noise parameters to the noise generator and the filter.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a novel noise deep brain stimulation system based on time-delay feedback control. Background technique [0002] Parkinson's disease is caused by the lack of a neurotransmitter called dopamine in the brain. The lack of dopamine will cause changes in the firing rate and firing pattern of neurons, accompanied by the appearance of beta frequency bands in neurons in the basal ganglia of the brain (12 -35Hz) synchronous discharge phenomenon. Pathological synchronous discharge phenomenon will seriously affect the ability of the thalamus to respond to external stimuli, that is, the reliability of the thalamus will be reduced, so Parkinson's patients will appear symptoms such as resting tremor, slow movement, and inability to move. The existing method for relieving the above symptoms is mainly based on deep brain stimulation (DBS), which can effectively weaken the synchronous discha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36A61N1/05A61B5/0476A61B5/0478
CPCA61N1/36067A61N1/0534A61N1/36132A61N1/36135A61B5/291A61B5/369
Inventor 刘晨孟紫寒于海涛王江朱晓东张伟李琪邢梦娅刘静张志勇
Owner TIANJIN UNIV
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