Application of let-7b and rSjp40 (recombinant Schistosoma japonicum p40) in preparation of drug for preventing or treating schistosoma infected hepatic fibrosis

A technology of let-7b and liver fibrosis, applied in the field of genetic engineering, can solve the problems of little attention and no research on treatment methods, and achieve the effect of solving liver fibrosis caused by schistosome infection
CN110684841APending Publication Date: 2020-01-14NANTONG UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANTONG UNIVERSITY
Publication Date
2020-01-14

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Abstract

The invention provides application of let-7b and rSjp40 (recombinant Schistosoma japonicum p40) in preparation of a drug for preventing or treating schistosoma infected hepatic fibrosis. The application is mainly shown as follows: (1) rSjp40 up-regulates expression of let-7b and promoter thereof in a human LX-2 cell line; (2) let-7b participates in the activation process of inhibiting human hepatic stellate cells (HSCs) by the rSjp40; and (3) the rSjp40 can promote increase of expression of let-7b in hepatic tissue and is in negative correlation with expression of collagen. By the function andmolecular mechanisms of rSjp40 in inhibiting the let-7b in the activation process of the HSCs, schistosoma infected hepatic fibrosis is inhibited at the gene level, the application of the let-7b andrSjp40 in preparation of the drug for preventing or treating schistosoma infected hepatic fibrosis is obtained, and the problem of schistosoma infected hepatic fibrosis is expected to be solved in thefuture.
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Description

technical field

[0001] The invention belongs to the field of genetic engineering, and specifically relates to the application of let-7b and rSjp40 in the preparation of drugs for preventing or treating hepatic fibrosis infected by Schistosoma japonicum. Background technique

[0002] Liver fibrosis is a reversible wound healing process aimed at maintaining organ integrity. Fibrosis is usually caused by chronic liver injury caused by various factors, mainly viral infection, schistosomiasis and alcoholism, etc. Although many drugs have been shown to have anti-fibrotic activity in vitro and in animal models, none of these drugs has been proven clinically effective.

[0003] Hepatic stellate cells (HSCs) produce collagen during their initiation, progression, and regression by secreting fibrotic factors that promote portal fibroblasts, fibroblasts, and bone marrow-derived myofibroblasts, thereby forming fibrosis. Understanding the molecular mechanism of liver fibrosis and its re...

Claims

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