Detection, treatment and prognosis target of depression and applications

A depression and target technology, applied in the field of biomedicine, can solve the problem of less research on down-regulated genes

Active Publication Date: 2020-01-31
THE SECOND HOSPITAL OF SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although HDAC inhibitors reverse the effects of chronic overcoming stress strikingly similar to clinical antidepressant treatments, there is currently no direct evidence of whether specific histone deacetylase inhibitors act as important mediators of antidepressants, let alone HDAC targets. process of gene regulation
At present, there are few studies on down-regulated genes regulated by specific histone deacetylases

Method used

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  • Detection, treatment and prognosis target of depression and applications
  • Detection, treatment and prognosis target of depression and applications
  • Detection, treatment and prognosis target of depression and applications

Examples

Experimental program
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Embodiment 1

[0024] Materials and methods

[0025] C57BL / 6 J mice aged 6-8 weeks, weighing 23-25g, and CD-1 mice aged 8-9 months were used. All mice were placed in standard cages with controlled temperature (22±2° C.) and a daylight / dark cycle of 12 hours. Food and water are readily available. All animal procedures were performed in accordance with the guidelines of the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal Care and Use Committee of Shandong University.

[0026] chronic social defeat stress

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Abstract

The invention belongs to the technical field of biomedicine, and relates to a detection, treatment and prognosis target of depression and applications. An accumbens nucleus HDAC7 in neurons can be inhibited by a small hairpin RNA in an HDAC7-shrna lentivirus, and the sequence of the small hairpin RNA is 5'-GAC AAG AGC AAG CGA AGT G-3'. Experiments in the invention confirm that the HDAC7 can regulate and control the expression of many genes closely related to depression-like behavior and can be used as the detection, treatment and prognosis target of the depression; and the target provides a novel idea for the treatment of the depression, and provides a novel idea for the research and development of drugs for preventing and treating the depression.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to a depression detection, treatment and prognosis target and its application. Background technique [0002] According to the "Global Health Estimates" released by the World Health Organization in 2017, the total number of patients with depression worldwide is 322 million, and nearly half of them live in Southeast Asia and the Western Pacific region. Although depression has been reported to have a strong genetic component and involves abnormal changes in gene expression. Accumulating evidence indicates that histone acetylation and histone deacetylases dynamically regulate the level of histone acetylation. Epigenetic mechanisms are evident in animal models of depression induced by chronic socially enforced stress. [0003] One of the most intriguing features linking epigenetic mechanisms to psychiatric disorders is their ability to respond to, integrate, and translate various env...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/55A61K31/7088A61K45/00A61P25/24C12Q1/6883
CPCA61K31/7088A61K45/00A61P25/24C12N9/80C12Q1/6883C12Q2600/118C12Q2600/158C12Y305/01098
Inventor 靖旭武静郑惠延王道清宋妍
Owner THE SECOND HOSPITAL OF SHANDONG UNIV
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