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Biomarkers and their application for early detection of severity and prognosis of aneurysmal subarachnoid hemorrhage

A biomarker, subarachnoid technology, applied in the field of molecular diagnosis and molecular biology, to improve the effect of diagnosis and treatment

Active Publication Date: 2021-06-01
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, regarding the H in the CSF of aSAH patients and rats 2 The expression of S-generating enzymes has rarely been reported

Method used

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  • Biomarkers and their application for early detection of severity and prognosis of aneurysmal subarachnoid hemorrhage
  • Biomarkers and their application for early detection of severity and prognosis of aneurysmal subarachnoid hemorrhage
  • Biomarkers and their application for early detection of severity and prognosis of aneurysmal subarachnoid hemorrhage

Examples

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Embodiment 1

[0055]Patient CSF sample acquisition: This study selected 40 patients with CSF specimens of patients with intracranial aneurysms in Thailant Central Hospital in January 2018. This research program is approved by the Ethics Committee of Tai'an Central Hospital (No. 2016-05-003). Patients involved in embolization and aneurysm craniotomy. The severity of damage is referred to the GCS score, hunt-hess grading. The MRS Review Branch was used to follow-up evaluation of the MRS review Branch.

[0056]Incorporate standards and exclusion criteria: (1) between 40 and 70 years old, (2) accepts simple interventional embolism treatment, (3) SAH-liable aneurysm. Excluding criteria: (1) Transfer to craniotherapy in the treatment of craniotomy; (2) SAH caused by multiple responsible aneurysms; (3) blood vessels during surgery; (4) Early cerebral infarction; (5) died within 6 months after surgery. Finally, 18 patients were included. In addition, in this study, we provided 2 cases of clinical case mater...

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Abstract

The invention provides a marker for early detection of aneurysmal subarachnoid hemorrhage severity and prognosis assessment and application thereof, belonging to the technical fields of molecular diagnosis and molecular biology. The present invention verifies the existence of CBS, DAO and 3-MST in CSF and its correlation with the inflammatory parameters of SAH patients and rats by observing and verifying that the expression levels of CBS, DAO and 3-MST are correlated with the prognosis of patients, thereby It can be used as a biomarker for early detection of the severity and prognosis of aneurysmal subarachnoid hemorrhage, providing a new method for the monitoring and prognosis of aSAH, and helping to improve the diagnosis and treatment of this type of disease.

Description

Technical field[0001]The present invention belongs to the field of molecular diagnosis and molecular biology, and is specifically related to biomarkers and their applications for early detection of severity and prognostic assessment of anti-blood bleeding of anneuryalic subaracine.Background technique[0002]The information disclosed in the background is only intended to increase the understanding of the overall background of the present invention, and is not necessarily considered to recognize or imply that the information is intended to be a prior art known to those of ordinary skill in the art.[0003]AneurySmal Subarachnoid Hemorrhage, ASAH is a severe endanger of cerebrovascular disease, high incidence and mortality. In recent years, acute damage (early brain injury) in 72 hours after ASAH is considered to be the main cause of prognosis. Its pathological process is complex, mainly including mitochondrial dysfunction, inflammation, oxidation cascade, cerebral edema, cell death, bloo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/527C12Q1/48C12Q1/26G01N33/68
CPCC12Q1/26C12Q1/48C12Q1/527G01N33/6869G01N33/6893G01N2333/5412G01N2333/90644G01N2333/91194G01N2800/2871G01N2800/52
Inventor 王贞韩敏刘德祥
Owner SHANDONG UNIV