Application of cobra neurotoxin polypeptide molecules to treatment of nephritis albuminuria

Abstract

After a nephritis patient suffers from nephritis for several years, albumin in a little blood begins to leak into urine, at the moment, albumin leakage is easy to neglect because clinical symptoms arenot significant or the albumin is confused with other albuminuria caused by hypertension and hyperlipaemia, so that the illness state is worsened. But when it is found that other indexes reflecting renal functions, such as [beta]2 microglobulin, [alpha]1 microglobulin, transferrin and immunoglobulin are also obviously increased in urine, the situation confirms that the renal functions already have pathology changes. At present, no other effective methods exist except hormone on treatment, but long-term hormone treatment can cause many side reactions to the patient. If illness course freely develops, more albumin leaks into urine, and kidney damage can be further worsened. Cobra neurotoxin polypeptide molecules can effectively reduce leak of various albumin in urine, control and delay kidney pathologic progress, improve renal functions and have important significance in treatment of the nephritis through restraining autoimmunity inflammatory reactions of the kidney.

Description

Background technique: [0001] Nephritis is a group of glomerulopathy-based diseases with multiple etiologies, which can be divided into primary nephritis and secondary nephritis. Primary nephritis may be caused by various bacterial, viral or protozoan infections through immune mechanisms, inflammatory factors, and non-immune mechanisms; secondary nephritis may include diabetes, hypertension, allergic purpura, and systemic lupus erythematosus , Multiple renal cysts, gouty nephropathy and other causes. Regardless of whether it is primary or secondary, due to the lack of effective treatment drugs at present, a considerable number of patients will develop chronic nephritis, which is protracted and difficult to heal. If the development of nephritis cannot be prevented, the worst clinical stage of renal failure cannot be avoided. . [0002] In the traditional concept, routine urine protein, blood urea nitrogen BUN, and serum creatinine Cr are indicators for judging kidney damage. H...

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[25] And it is this synergy that leads to fatal consequences

[26] In a study of how black mambas (cobra) venoms lead to high mortality, scientists found that potassium channel blocking activity is only one of many pathways, and that different toxins act in different Synthetic toxicity induced at the organ level is the concern for high mortality

[29] Physically modified Chinese cobra snake venom may reduce the toxicity of snake venom, but as a mixture, the composition is complex and the quality control is difficult, so there is still the possibility of synergy between the toxins

Neurotoxin mixtures are safer than snake venoms because they have removed a series of toxins such as cardiotoxins, cytotoxins, and phospholipase A2, reducing the severe toxicity of mixed snake venoms due to synergistic effects, but they are still The mixture of several neurotoxins still has the possibility of causing synergistic effects. For example, a side reaction of the cobra neurotoxin mixture "cobotide" may cause respiratory depression

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