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A skin care product suitable for the skin of diabetic patients

A technology for skin care products and diabetes, which is used in skin care preparations, skin diseases, medical preparations containing active ingredients, etc.

Active Publication Date: 2022-06-07
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This shows that although the American cockroach extract can improve and moisturize the skin, it has been found in practice that frequent and excessive use of products containing natural components of the American cockroach extract will cause side effects, which will cause excessive proliferation of granulation tissue and collagen fiber deposition such as image 3 (A), resulting in skin scarring

Method used

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  • A skin care product suitable for the skin of diabetic patients
  • A skin care product suitable for the skin of diabetic patients
  • A skin care product suitable for the skin of diabetic patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of raw materials

[0048] 1.1 Preparation of Periplaneta americana extract

[0049] 1.1.1 Extraction of Periplaneta americana extract 1

[0050] The extraction method of the Periplaneta americana extract is as follows: select adult Periplaneta americana with full worms and dry it in a dryer at 60°C; 10 times the amount of 95% ethanol is used as a solvent for immersion for 2 weeks; ethanol reflux extraction 3 times, each The extraction time is 1h, the remaining extract is soaked in 10 times the volume of aqueous solution for 4h, and then extracted twice, the two extraction times are 1h respectively, the water extraction solutions are combined, concentrated under reduced pressure and dried to obtain the water extract, namely Periplaneta americana Extract.

[0051] 1.1.2 Extraction of Periplaneta americana extract 2

[0052] The difference from 1.1.1 is that the drying temperature is 80°C, 8 times the volume of 95% ethanol is used as a solvent to s...

Embodiment 2

[0058] Example 2: Experiment on the effect of Periplaneta americana extract on wound healing of vascular endothelial cells

[0059] In order to observe the effect of Periplaneta americana extract on the proliferation and angiogenesis of vascular endothelial cells, 2.0×10 6 The vascular endothelial cell line, human umbilical vein endothelial cells (HUVEC), was seeded at a density of 1 cells / mL in six-well plates with 2 ml of F-12K medium containing 10% fetal bovine serum and 1% penicillin / streptomycin per well. , and incubated in a cell incubator. After the cells had adhered, a cell scratch was prepared using the tip of a sterile 10 μl pipette, and floating cells were gently washed away from the scratch with PBS. The cells were treated with different concentrations of Periplaneta americana extract to observe its healing effect on scratches, and serum-free medium without samples was used as blank control. Scratch pictures were taken at 0, 12 and 24 h using an inverted microsco...

Embodiment 3

[0061] The preparation of embodiment 3 cream and skin care efficacy test for diabetic patients

[0062] 3.1 Preparation method of face cream

[0063] 3.1.1 Preparation of cream 1

[0064] (1) Prepare raw materials by mass percentage: Periplaneta americana extract: 4%, Dianzhonglou extract: 0.5%, stearyl alcohol: 5%, caprylic / capric triglyceride: 3%, cetearyl alcohol : 3%; Squalane: 4%, Triglyceride (ethylhexanoate): 3%, Dimethicone: 0.5%, Disodium EDTA: 0.1%, Carbomer: 1%, Sodium Hyaluronate: 0.05%, 1,3-Propanediol: 5%, Glycerin: 4%, L-Arginine: 0.5%, Allantoin: 0.3%, Dipotassium Glycyrrhizinate: 0.1%, Go Ionized water makes up the balance; the sum of the above components is 100%;

[0065] (2) Place sodium hyaluronate, 1,3-propanediol and glycerin in an emulsifying pot, turn on stirring, and rotate at 35-45 r / min, then add 50% water of the total components into the emulsifying pot, and add carbomer to the emulsifying pot. Sprinkle slowly into the pot with stirring, keep st...

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Abstract

The invention discloses a skin care product containing Periplaneta americana extract suitable for the skin of diabetic patients, which belongs to the technical field of cosmetics. The active ingredients of the skin care product protected by the present invention are the extract of Periplaneta americana, the extract of Pachyphyllum yunnanensis and the auxiliary materials used in daily cosmetics and skin care products. The active ingredients of the present invention, Periplaneta americana and P. diatriana, as active ingredients for beauty and moisturizing, have a remarkable effect on the skin of diabetic patients. In particular, the addition of the active ingredients of P. americana extract makes the synergistic effect of the extract of Periplaneta americana and the matrix It has better transdermal absorption, stronger antibacterial effect, and better skin repair effect. It has a very good curative effect on pigmented sunken scars on the skin of diabetic patients, and largely relieves the single or excessive use of Periplaneta americana. , causing side effects of skin wound scars, and has a good application prospect.

Description

technical field [0001] The invention discloses a cosmetic for skin care of diabetic patients, in particular to a skin care product containing Periplaneta americana extract suitable for the skin of diabetic patients, belonging to the technical field of cosmetics. Background technique [0002] According to the latest data released by the International Diabetes Federation, the number of diabetic patients worldwide has reached 425 million, and it is estimated that by 2045, the number of diabetic patients may reach 629 million. The number of diabetic patients in China is about 114.4 million, which has become the country with the largest number of patients. The World Health Organization has listed "diabetes" as one of the three difficult diseases, and its prevention and treatment has become one of the key and hot areas of global medical research. Diabetic dermatopathy, as one of the most common complications of diabetes, occurs in various stages of diabetes and can damage the ski...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/9794A61Q19/00A61Q19/02A61Q17/00A61P3/10A61P17/02
CPCA61K8/987A61K8/9794A61Q19/00A61Q19/02A61Q17/005A61P3/10A61P17/02A61K2800/5922
Inventor 陆地吕乐春陈真韩毅桂莉
Owner KUNMING MEDICAL UNIVERSITY
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