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Metal organic framework material and preparation method thereof, and applications of metal organic framework material in identification of chiral polysaccharides

A metal-organic framework and chiral technology, which is applied in the direction of analytical materials, luminescent materials, and material excitation analysis, can solve the problems of ineffectiveness and harmfulness, and achieve the effects of high yield, simple operation, and easy amplification

Pending Publication Date: 2020-02-14
孝感市思远新材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With chiral drugs, one isomer may be effective while the other may be ineffective or even harmful

Method used

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  • Metal organic framework material and preparation method thereof, and applications of metal organic framework material in identification of chiral polysaccharides
  • Metal organic framework material and preparation method thereof, and applications of metal organic framework material in identification of chiral polysaccharides
  • Metal organic framework material and preparation method thereof, and applications of metal organic framework material in identification of chiral polysaccharides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1a

[0033] Combine 57mg of (R)-BINOL-Ligand with 60mg of Zn(NO 3 ) 2 .6(H 2 (0), adding 3 mL of DMF and 3 mL of ethanol, and standing at 100° C. for 10 h to obtain colorless transparent crystal R-CMOF-1 with a yield of 91%.

[0034] The PXRD of R-CMOF-1 as figure 1 shown.

Embodiment 1b

[0036] Combine 57mg of (R)-BINOL-Ligand with 54mg of Zn(NO 3 ) 2 .6(H 2 0), adding 3mL DMF and 2.5mL methanol, standing at 80°C for 12h, to obtain colorless transparent crystal R-CMOF-1.

Embodiment 1c

[0038] Combine 57mg of (R)-BINOL-Ligand with 66mg of Zn(NO 3 ) 2 .6(H 2 (0), add 4mL DMF and 3.5mL isopropanol, and stand at 100°C for 12h to obtain colorless transparent crystal R-CMOF-1.

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Abstract

The invention discloses a metal organic framework material and a preparation method thereof, and applications of the metal organic framework material in identification of chiral polysaccharides, wherein the metal organic framework material is a coordination polymer with a microporous network structure formed by self-assembly of metal ions and a compound A, a molar ratio of the metal ions to the compound A is 2:1, the metal ions are selected from Zn<2+>, Cd<2+> and Cu<2+>, and the compound A is selected from (R)-BINOL-Ligand as shown in a formula I or (S)-BINOL-Ligand as shown in a formula II.The metal organic framework material of the invention can quickly identify chiral polysaccharide compounds.

Description

technical field [0001] The invention relates to the field of chiral polysaccharide recognition, in particular to a metal organic framework material, its preparation and its application in the recognition of chiral polysaccharides. Background technique [0002] Chirality is one of the essential properties of nature. Biomacromolecules, such as proteins, polysaccharides, nucleic acids and enzymes, which are the important basis of life activities, are almost all chiral. These small molecules often have important physiological functions in the body. Most of the drugs currently used are small organic molecules composed of less than 50 atoms, and a large part of them are also chiral. Their pharmacological effects are realized through strict chiral matching and molecular recognition with macromolecules in the body. There are significant differences in the pharmacological activity, metabolic process and toxicity of the enantiomers of chemical drugs containing chiral factors in the h...

Claims

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Application Information

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IPC IPC(8): C08G83/00C09K11/06G01N21/64
CPCC08G83/008C09K11/06C09K2211/188G01N21/643G01N2021/6432
Inventor 刘思
Owner 孝感市思远新材料科技有限公司