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Biocompatible alkaline-earth metal peroxide nano preparation as well as preparation method and application thereof

A biocompatible, alkaline earth metal technology, applied in the field of nano-biomedicine and imaging, can solve the problems of low yield, low drug loading rate, unfavorable technology transformation, etc., achieve high loading rate, and reduce long-term retention in the body Hidden dangers, effects of good biocompatibility

Inactive Publication Date: 2020-03-06
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process of this responsive polymer is very complicated, the yield is low, and the drug loading rate is low, which is not conducive to technology transfer.

Method used

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  • Biocompatible alkaline-earth metal peroxide nano preparation as well as preparation method and application thereof
  • Biocompatible alkaline-earth metal peroxide nano preparation as well as preparation method and application thereof
  • Biocompatible alkaline-earth metal peroxide nano preparation as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Weigh 10mmol (1470.20mg) CaCl2 2H 2 O powder, dissolved in 5 mL of deionized water for later use. Weigh 15mg of sodium hyaluronate powder, dissolve it completely with 10mL of NaOH aqueous solution (1mol / L) ultrasonically, then neutralize it with dilute hydrochloric acid aqueous solution to neutrality, then add deionized water to 30mL, and finally obtain 0.5mg / mL transparent Sodium hyaluronate neutral aqueous solution for standby. Get the mass concentration of 0.5mL and be 30% hydrogen peroxide solution, dilute 10 times with deionized water, obtain the 3% hydrogen peroxide solution for subsequent use.

[0038] (2) Measure 60mL of anhydrous methanol with a graduated cylinder, add it to a blank transparent glass reaction bottle, and add a clean magnet, place it on a magnetic stirrer and stir at a speed of 300 rpm.

[0039] (3) Use a pipette to draw 1mL of calcium chloride aqueous solution and 1mL of sodium hyaluronate aqueous solution, slowly add dropwise to the anhy...

Embodiment 2

[0045] (1) Weigh 10mmol (1761.80mg) of calcium acetate monohydrate and dissolve it in 10mL of deionized water for later use. Weigh 15mg of sodium hyaluronate powder, dissolve it completely with 10mL of NaOH aqueous solution (1mol / L) ultrasonically, then neutralize it with dilute hydrochloric acid aqueous solution to neutrality, then add deionized water to 30mL, and finally obtain 0.5mg / mL transparent Sodium hyaluronate neutral aqueous solution for standby.

[0046] (2) Use a graduated cylinder to measure 60 mL of absolute ethanol, add it to a blank transparent glass reaction bottle, and add a clean magnet, place it on a magnetic stirrer and stir at a speed of 300 rpm.

[0047] (3) Use a pipette to draw 1mL of calcium acetate aqueous solution and 1mL of sodium hyaluronate aqueous solution, slowly add dropwise to the absolute ethanol solution, and continue magnetic stirring for 5 minutes to fully mix.

[0048] (4) Use a pipette to draw 0.1 mL of 30% hydrogen peroxide solution a...

Embodiment 3

[0052] (1) Weigh 10mmol (2033.00mg) MgCl 2 ·6H 2 O powder, dissolved in 5mL of deionized water for later use. Weigh 15mg of sodium hyaluronate powder, dissolve it completely with 10mL of NaOH aqueous solution (1mol / L) ultrasonically, then neutralize it with dilute hydrochloric acid aqueous solution to neutrality, then add deionized water to 30mL, and finally obtain 0.5mg / mL transparent Sodium hyaluronate neutral aqueous solution for standby.

[0053] (2) Use a graduated cylinder to measure 60 mL of absolute ethanol, add it to a blank transparent glass reaction bottle, and add a clean magnet, place it on a magnetic stirrer and stir at a speed of 300 rpm.

[0054] (3) Use a pipette to draw 1mL of magnesium chloride aqueous solution and 1mL of sodium hyaluronate aqueous solution, slowly add them dropwise to the absolute ethanol solution, and continue magnetic stirring for 5 minutes to make them fully mixed.

[0055] (4) Use a pipette to draw 0.1mL of hydrogen peroxide solution...

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Abstract

The invention discloses a biocompatible alkaline-earth metal peroxide nano preparation as well as a preparation method and an application thereof. The method is a normal-temperature one-step water-phase synthesis method, the sodium hyaluronate-coated alkaline-earth metal peroxide nano preparation is directly prepared in a water-alcohol mixed solvent system, and the sodium hyaluronate-coated alkaline-earth metal peroxide nano preparation has good in-vivo biocompatibility and can be used as an anti-tumor nano preparation. The nano preparation has the characteristics that (1) the raw materials are cheap and easy to obtain; (2) the method is simple and rapid, does not need special expensive equipment, and is suitable for expanded scale production; (3) active hydrogen peroxide with a tumor killing effect and a metal ion component are contained, and can be degraded and released through a tumor acidic microenvironment; and (4) the particle size is smaller than 100 nanometers, and circulationand rapid metabolism in a living body are facilitated. According to the nano preparation disclosed by the invention, the tumor tissue is specifically killed and proliferation is inhibited by utilizingthe characteristics of the acidic microenvironment of the tumor tissue, so that the nano preparation has very important application potential in clinical medicine.

Description

technical field [0001] The invention belongs to the category of nano-biomedicine and imaging, and relates to the preparation of an alkaline-earth metal peroxide nano-preparation with good biocompatibility and its application in the preparation of tumor therapeutic drugs, specifically, the preparation of an alkaline-earth metal Peroxide nano-formulations, and their use as tumor therapeutics. The nano-preparation will not cause damage to normal tissues and organs in the living body, and has good biocompatibility, but after being enriched in the tumor site, it will degrade in response to the acidic microenvironment of the tumor, and release toxic components to kill tumor cells. imaging category. Background technique [0002] Nano-preparation has been extensively studied in the field of tumor treatment. Its main advantages are that it has a large specific surface area and is easy to carry out targeted modification and modification. Therefore, drug loading and targeted drug use ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K33/40A61K47/36A61P35/00
CPCA61K9/5161A61K33/40A61P35/00
Inventor 张盟步文博
Owner EAST CHINA NORMAL UNIVERSITY
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