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Manufacture process of soft capsule shells

A manufacturing process and soft capsule technology, applied in the field of soft capsule rubber manufacturing process, can solve problems such as uneven dispersion and sticky glue, and achieve the effect of uniform sol, simple process flow, and convenient addition

Inactive Publication Date: 2020-03-13
浙江仙琚医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pre-mixing of color indigo or sunscreen also requires water or glycerin. If the amount of purified water in the rubber prescription is small, take out a part to pre-mix color indigo or sunscreen, resulting in less water in the sol, resulting in glue The liquid is very viscous, adding indigo or opacifying agent at this time will also cause uneven dispersion

Method used

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  • Manufacture process of soft capsule shells

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Embodiment

[0030] This embodiment provides a soft capsule rubber, which includes 9-11 parts of purified water, 0.1-0.5 parts of color lake / sunscreen agent, 9-11 parts of gelatin and 3-6 parts of glycerin. The following describes the soft capsule rubber manufacturing process in detail:

[0031] First step, high shear stage: extraction of purified water, and the lake / opacifier was dispersed in the purified water under high shear for 20 min.

[0032] The second step, the warm-up phase: the Add purified water and glycerin into the glue tank, and at 70°C to 90°C, add the dispersed color lake / opacifier in the high-shear stage into the glue tank; extract and use the remaining Rinse the inner wall of the chemical glue tank with purified water, stir evenly and let it stand for use;

[0033] The third step, the sol stage: add gelatin into the glue tank that has been preheated, and stir the sol for 3-5 minutes;

[0034] The fourth step, the first vacuuming stage: at a vacuum degree of -0.08M...

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Abstract

The invention discloses a manufacture process of soft capsule shells, comprising the following steps: extracting purified water and dispersing a lake / opacifying agent in the purified water under highshear for 20min; adding the purified water and glycerol into a glue-melting tank, and adding the lake / opacifying agent dispersed in the high shear stage into the glue-melting tank at 70-90 DEG C; extracting and flushing the inner wall of the glue-melting tank with the remaining purified water, stirring evenly, and standing for later use; adding gelatin into the glue-melting tank after the preheating stage, and stirring collosol for 3-5min; vacuum-pumping for 1-2 min when the vacuum degree is from minus 0.08 MPa to minus 0.09 MPa; keeping the vacuum state of the glue-melting tank, stirring thecollosol until there is no colloidal particles in the collosol; readjusting the vacuum degree of the glue-melting tank to the range of minus 0.08 MPa to minus 0.09 Mpa, and vacuum-pumping for 30-120 min to obtain a colloidal fluid; releasing the vacuum of the glue-melting tank, filtering the colloidal fluid with a 40-mesh sieve, injecting the colloidal fluid into a heat preservation tank of 50-60DEG C, and standing for 8-24h; and performing injection molding.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a soft capsule rubber manufacturing process. Background technique [0002] Soft capsules are a type of capsules commonly found in medicine or health food. It is a capsule made by sealing liquid medicine or liquid fruit medicine in a soft capsule. At present, the existing soft capsule materials are mainly made of gelatin, glycerin or other suitable pharmaceutical excipients for capsules alone or in combination. There are problems such as uneven dispersion in the existing soft capsule rubber manufacturing process, such as the US patent with the patent publication number US20150148323A, which first mixes water and glycerin and heats it, then adds gelatin to carry out colloidal sol, and then adds pre-mixed color indigo or Shading agent, after stirring evenly, vacuumize. This process adopts one-time vacuuming, which has the following problems: [0003] First, the process has requ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/10
CPCA61K9/4816A61K9/4825
Inventor 李健孙影任潇潇张东瑞姜林涛
Owner 浙江仙琚医药科技有限公司
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