Application of CA125 to curative effect evaluation of primary liver cancer stereotactic radiotherapy

A technology for CA125 and primary liver cancer, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems that primary liver cancer does not have good diagnostic performance and prognosis evaluation performance
CN110907646AActive Publication Date: 2020-03-24WENZHOU MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
WENZHOU MEDICAL UNIV
Publication Date
2020-03-24

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Abstract

The invention discloses an application of CA125 as curative effect evaluation molecular marker to stereotactic radiotherapy (SBRT) of a primary liver cancer patient with a tumor marker negative (CA125 is less than 35.0 U / ml). For CA125 negative primary liver cancer patients, if the serum CA125 concentration is higher than that before treatment 6 months after SBRT treatment, the prognosis is predicted to be poor. When the rising ratio is higher than 150%, the prognosis of the patient is poor for one year and two years; and when the rising ratio is higher than 23%, the prognosis of the patientis poorer for 3 years and 5 years. The invention provides a method for prognosis evaluation of CA125-negative primary liver cancer patients after SBRT treatment for 1-5 years, and the method has important significance in improving the survival rate of liver cancer and reducing the death rate.
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Description

technical field

[0001] The invention belongs to the applied field of molecular biology. Specifically, the present invention relates to the application of cancer antigen CA125 in the evaluation of the curative effect of stereotactic radiotherapy for primary liver cancer patients with negative tumor markers. Background technique

[0002] Primary liver cancer is one of the most common malignant tumors in the world. According to global cancer statistics in 2018, there were more than 841,000 newly diagnosed primary liver cancers and 782,000 related deaths. It accounts for about 50% of the total cases and deaths worldwide. Primary liver cancer is also one of the most common malignant tumors in China, and its morbidity and mortality rank the fourth and second among malignant tumors in my country, respectively. At present, there are various treatment methods for primary liver cancer. Surgical treatment includes radical surgical resection and liver transplantation; non-surgical tre...

Claims

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