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Biomarkers for atherosclerotic cardiovascular diseases

An atherosclerosis, biomarker technology, applied in the determination/examination of microorganisms, biochemical equipment and methods, DNA/RNA fragments, etc., can solve the problem of lack of metagenomics to characterize large research cohorts and hinder research.

Pending Publication Date: 2020-03-24
SHENZHEN HUADA GENE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, lack of a large study cohort for metagenomic characterization of this major population of ACVD hampers further investigation of the role played by the microbiome

Method used

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  • Biomarkers for atherosclerotic cardiovascular diseases
  • Biomarkers for atherosclerotic cardiovascular diseases
  • Biomarkers for atherosclerotic cardiovascular diseases

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0024] An embodiment of the third broad aspect of the present disclosure provides a method of predicting the risk of atherosclerotic cardiovascular disease or a related condition thereof. According to an embodiment of the present invention, the method includes: (1) determining the relative abundance of the above-mentioned biomarkers in the sample of the test subject; and (2) predicting atherosclerosis based on the relative abundance of the above-mentioned biomarkers risk of sclerotic cardiovascular disease or its related conditions. The above method can effectively predict the risk of atherosclerotic cardiovascular disease or its related conditions. The reliability of the prediction results is high.

[0025] According to an embodiment of the present disclosure, wherein the relative abundance of the biomarkers is obtained by sequencing.

[0026] According to an embodiment of the present disclosure, step (2) includes comparing the relative abundance of the biomarker with a pre...

Embodiment

[0035] Identification of 3 biomarkers to assess ACVD risk

[0036] Sample Collection

[0037] Samples from 405 subjects, including 218 individuals with ACVD and 187 control subjects, were collected at the Medical Research Center of Guangdong General Hospital. Individuals with ACVD exhibit clinical manifestations of stable angina, unstable angina, or acute myocardial infarction (AMI) (Table 1). ACVD diagnosis was confirmed by coronary angiography, and individuals with ≥50% stenosis in single or multiple vessels were enrolled. All patients were of Chinese Han nationality, unrelated, aged between 40 and 80 years old. Exclusion criteria included persistent infectious disease, cancer, renal or hepatic failure, peripheral neuropathy, stroke, and antibiotic use within one month of sample collection. At the time of physical examination, all enrolled healthy control individuals were free of clinically significant symptoms of ACVD. Demographic data and cardiovascular risk factors w...

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Abstract

Disclosed are a biomarker, the use of the biomarker in predicting the risk of atherosclerotic cardiovascular disease or related disorder thereof, and a method of predicting the risk of atheroscleroticcardiovascular disease or related disorder thereof.

Description

technical field [0001] Embodiments of the present disclosure relate generally to the field of bioassays, and more specifically, to biomarkers, the use of said biomarkers in predicting the risk of atherosclerotic cardiovascular disease or related disorders, predicting atherosclerotic A method of risk of atherosclerotic cardiovascular disease or a related condition thereof and a kit for predicting the risk of atherosclerotic cardiovascular disease or a related condition thereof. Background technique [0002] Atherosclerotic cardiovascular disease (ACVD) is usually caused by the buildup of plaque (ie, atherosclerosis) on the walls of arteries, especially the medium and large arteries that serve the heart. It refers to the following conditions: coronary heart disease (CHD), cerebrovascular disease, peripheral arterial disease, and aortic atherosclerotic disease. These conditions have similar causes, mechanisms, and treatments. [0003] The "gold standard" for detecting ACVD is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q1/689C12Q2600/158
Inventor 揭著业夏慧华梁穗莎贾慧珏
Owner SHENZHEN HUADA GENE INST
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