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A new anti-breast cancer application of Lasmeline

An anti-breast cancer and lameline technology, which is applied in the field of medicine, can solve the problems of breast cancer research and biological activity report and the like, and achieve the effect of inhibiting cell proliferation.

Inactive Publication Date: 2021-10-01
HAIMEN MAOFA ART DESIGN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is currently no relevant research and biological activity reports of Lasmeline on breast cancer.

Method used

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  • A new anti-breast cancer application of Lasmeline
  • A new anti-breast cancer application of Lasmeline
  • A new anti-breast cancer application of Lasmeline

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Test materials

[0018] Human breast cancer MCF-7 and MDA-MB-231 cells were cryopreserved in our laboratory and used after recovery according to conventional methods.

[0019] Fetal bovine serum and RPMI 1640 medium were purchased from Gbico, USA.

[0020] Penicillin, streptomycin, and trypsin were purchased from Biyuntian Biotech.

[0021] Suxin Lamei alkali is stored dry, with a purity of not less than 95%.

[0022] The brand of 96-well plate and 6-well plate is Corning.

[0023] 2. Test method

[0024] 1. Culture of human breast cancer MCF-7 and MDA-MB-231 cells

[0025] Place human breast cancer MCF-7 and MDA-MB-231 cells in RPMI 1640 medium containing 10% fetal bovine serum, 100IU / mL penicillin and 100IU / mL streptomycin at 37°C, 5% CO 2 Routine culture in the incubator, with 0.25% trypsin digestion passage. Cells in the logarithmic growth phase were used for subsequent experiments.

[0026] 2. Cell Proliferation Inhibition Experiment

[0027] Take 2.5×10...

Embodiment 2

[0042] An anti-breast cancer tablet, the formula of which comprises 10 mg of lasumeline, 90 g of starch and 3 g of magnesium stearate.

[0043] Preparation process: take Suxin Lamei alkali, add starch, and magnesium stearate, mix evenly, make granules, dry, and compress into tablets.

Embodiment 3

[0045] An anti-breast cancer capsule, the formula of which includes 10 mg of lasumeline, 90 g of starch and 3 g of magnesium stearate.

[0046] Preparation process: take Suxin Lamei alkali, add starch, and magnesium stearate, mix evenly, make granules, dry, and pack into capsules.

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Abstract

The invention discloses a new anti-breast cancer application of lasmeline. The examples of the present invention show that lasumeline can effectively inhibit the proliferation of human breast cancer cells and hinder the growth of human breast cancer, so it can be used to prepare anti-breast cancer drugs for the treatment of breast cancer. Lameline may inhibit the proliferation of human breast cancer cells by acting on the P53 / BCL‑2 protein in the apoptosis pathway.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new anti-breast cancer application of lasmeline. Background technique [0002] Breast cancer is a phenomenon in which breast epithelial cells proliferate uncontrollably under the action of various carcinogenic factors. In the early stage of the disease, symptoms such as breast lumps, nipple discharge, and axillary lymph node enlargement are often manifested. In the late stage, cancer cells may metastasize to distant places and cause multiple organ lesions, which directly threaten the lives of patients. Breast cancer is often called the "pink killer", and its incidence rate ranks first among female malignant tumors, while male breast cancer is relatively rare. With the improvement of medical treatment, breast cancer has become one of the solid tumors with the best curative effect. According to the latest data from the International Agency for Research on Cancer (IARC) surve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61K36/185A61P35/00
CPCA61K36/185A61P35/00
Inventor 朱阳晨赵玲
Owner HAIMEN MAOFA ART DESIGN CO LTD