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Promoting hair growth and treatment of hair loss or excessive hair shedding

A hair growth, hair loss technique applied in the field of promoting hair growth and treating hair loss or excessive hair loss, which can solve the problems of variable results, disappointment, and greasy hair

Pending Publication Date: 2020-04-24
SAMSON CLINICAL PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Topical minoxidil has been recommended for CTE, however, results are variable and often disappointing
Many individuals also do not wish to apply lotion to the scalp as this may cause the hair to look greasy which may hinder compliance
Also, because minoxidil is broken down by the liver into minoxidil sulfate, high concentrations of topical minoxidil may have adverse effects on blood pressure
No FDA or TGA treatments are currently available for chronic telogen effluvium

Method used

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  • Promoting hair growth and treatment of hair loss or excessive hair shedding
  • Promoting hair growth and treatment of hair loss or excessive hair shedding
  • Promoting hair growth and treatment of hair loss or excessive hair shedding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Example 1: Preparation of sublingual minoxidil lozenges

[0120] Sublingual minoxidil (0.25 mg) lozenges containing sweetened mango flavor are prepared as follows:

[0121] Material: Minoxidil, Sweetened Mango Flavour Powder, base PCCA instant tablet powder TM (PCCA Rapid Dissolve Tablet Powder TM ).

[0122] Mixing process:

[0123] Determine the total weight of minoxidil to be incorporated into each tablet. Subtract the weight from step 1 from the amount of PCCA instant tablet powder base. The calculated amount is the weight of PCCA instant tablet powder base material that should be used for each tablet. When using Rapid Dissolve Tablet Mold, the ingredients required to fill the mold are 96 times. Preheat the convection oven to 110°C. It should be noted that Minoxidil remains stable for 30 minutes at a temperature of 110°C. Using the principle of geometric dilution, minoxidil, sweetened mango flavor powder and PCCA instant tablet powder base were wet-milled together w...

Embodiment 2

[0124] Example 2: Preparation of sublingual minoxidil polyglycerol lozenges

[0125] Prepare sublingual minoxidil (0.25 mg) polyglycerol lozenges as follows:

[0126] Material: Minoxidil, micronized silica gel (PPTD), flavoring agent, base material PCCA polyethylene glycol lozenges TM (PCCAPolyglycol Troche TM ).

[0127] Mixing process: In a beaker, melt the molten PCCA polyglycol lozenge base at 50°C-55°C while stirring (without performing melting in a microwave oven). Use a mortar and pestle to wet ground minoxidil and silica gel into a fine powder. Sieve the powder from step 2 into the molten base and stir until uniformly dispersed. Then add flavors and mix the composition thoroughly. The mixture was then poured into a mold and allowed to set at room temperature. The expiration date of lozenges prepared using the above scheme is expected to be 180 days.

Embodiment 3

[0128] Example 3: Preparation of 0.45 mg sublingual minoxidil or placebo small tablets

[0129] Prepare sublingual minoxidil tablets as follows:

[0130] Material: Minoxidil, microcrystalline cellulose (PH-102) (Fargon, #2059 / 165002784), polyethylene glycol 1450MW NF (base A; PCCA, #30-1013) and micronized silica gel PPTD (PCCA) #30-1009).

[0131] Mixing process: use laboratory film-cling film M TM (Lab Film-Parafilm M TM ) Cover one side of the mold. In an appropriately sized beaker, melt Base A at 50°C. Use a mortar and pestle to wet ground minoxidil or placebo together with microcrystalline cellulose (PH-102) wet ground and silica gel into a fine powder. Sieve the powder into the molten base while stirring. The use of a screen helps to ensure a small particle size. Discontinue heating and stirring until suspended. Using an appropriately sized syringe, dispense the molten mixture into a wet mill tablet 200 mg mold and allow it to coagulate at room temperature. The final ...

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PUM

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Abstract

The present invention relates to methods and compositions for treating hair loss or excessive hair shedding in a subject or for promoting hair growth in a subject. The present invention also relates to an orodispersible composition or a nasally administered composition comprising minoxidil for treating hair loss or excessive hair shedding in a subject or for promoting hair growth in a subject.

Description

Technical field [0001] The present invention relates to methods and compositions for treating excessive hair loss or hair loss in a subject or promoting hair growth in a subject. Background technique [0002] The hair follicles on the scalp do not produce hair continuously. Hair follicles cycle through a growth period that can last for two or more years, then return to a dormant period of up to three months, and then start to grow new hair fibers again. On a healthy human scalp, about 80% to 90% of hair follicles are growing hair at any time. These active hair follicles are in the so-called growth phase. This puts as much as 10% to 20% of the scalp hair follicles in a dormant state called telogen, when the hair follicles do not produce any hair fibers. Changes in the actual amount of hair loss occur in a variety of hair loss conditions, including growth phase hair loss, hair loss caused by chemotherapy, acute and chronic telogen loss, alopecia areata, cicatricial alopecia, and...

Claims

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Application Information

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IPC IPC(8): A61K31/506A61K9/20A61K9/10A61P17/14
CPCA61K31/506A61P17/14A61K9/0043A61K47/02A61K9/006A61K9/08A61K9/2009A61K9/2031A61K9/4866A61K31/277A61K31/4166A61K31/4439A61K31/57A61K31/58A61K31/585A61K45/06A61K2300/00A61K9/0056A61K33/14A61K9/10
Inventor 罗德尼·辛克莱
Owner SAMSON CLINICAL PTY LTD
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