A kind of pyrolysis type diterpene alkaloid compound and its preparation method and application

Abstract

The present invention provides a pyrolytic diterpene alkaloid compound represented by formula I, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, and a preparation method thereof. The present invention also provides the application of the compound or its salt, or its stereoisomer, or its solvate in the preparation of prevention and / or treatment of ventricular premature beats, ventricular tachycardia, and antiarrhythmic drugs, and the clinical prospect excellent.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pyrolysis type diterpene alkaloid compound and its preparation method and application. Background technique [0002] Arrhythmia is a clinically common and very dangerous cardiovascular disease. For a long time, people have been devoting themselves to the research of antiarrhythmic drugs, but there has been no obvious breakthrough in the past 20 years. [0003] Clinical treatment of arrhythmias can use antiarrhythmic drugs, or choose radiofrequency ablation and implantable automatic cardioverter defibrillator (ICD). [0004] Antiarrhythmic drugs still play an important role in the treatment of arrhythmias for the following reasons: (1) Most tachyarrhythmias require drugs to terminate the attack during acute attacks; (2) Some supraventricular premature beats and premature ventricular beats that cause symptoms need to be controlled with drugs and prevention of recurrence; ③Pa...

AI Technical Summary

Problems solved by technology

However, the processing principle of the sand-frying method has not been fully elucidated. How to transform the structure of the toxic alkaloid during the sand-frying process, and whether the toxicity of the transformed product is lower than that of the prototype alkaloid, and because the processing principle of the sand-frying method has not yet been clarified, the sand-stirred cannon The quality evaluation of products is still judged by subjective experience such as: the medicinal materials are fried until "the outer skin is browned and the section is yellow", and there is a lack of quantitative quality control indicators.

In addition, studies have shown that although some diterpene alkaloids have similar structures, they have opposite effects. For example, some can cause arrhythmia and have cardiotoxicity, while others have the effect of treating arrhythmia.

Images