A kind of in-situ colloidal hydrogel and its preparation method and application

An in-situ, glue technology, used in applications, pharmaceutical formulations, surgery, etc., can solve the problem of lack of hemostatic materials, and achieve excellent biocompatibility, rapid gelation time, and mild reaction conditions.

Active Publication Date: 2021-01-29
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there is currently no hemostatic material that can meet the above requirements

Method used

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  • A kind of in-situ colloidal hydrogel and its preparation method and application
  • A kind of in-situ colloidal hydrogel and its preparation method and application
  • A kind of in-situ colloidal hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1-10%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10-20% and 2-methacryloyl Add 1-3% of oxyethylphosphorylcholine (MPC) into deionized water, add a small amount of APS (0.5%-2%) to the mixed system, shake gently for a few seconds, and quickly form a gel.

[0031] Example 1

[0032] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 5%, (3-acrylamidopropyl) trimethylammonium chloride (AATAC) 15% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.

Embodiment 2

[0034] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10% and 2-methacryloyloxyethyl phosphoric acid Choline (MPC) 1% was added to deionized water, a small amount of APS (0.5%) was added to the mixed system, and after a few seconds of gentle shaking, the gel was formed rapidly.

Embodiment 3

[0036] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 8%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 20% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.

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PUM

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Abstract

The invention discloses an in-situ glue-forming gel and its preparation method and application. The in-situ glue-forming gel is prepared by free radical polymerization of dimethylaminopropyl acrylamide, (3-acrylamidopropyl) three Methylammonium chloride and 2‑methacryloyloxyethylphosphorylcholine are triggered by an initiator to quickly generate a gel in situ, and the gelation time is rapid, so as to achieve the effect of sealing and hemostasis. The in-situ gel forming hydrogel of the present invention can accurately control the proportion of raw materials during preparation, and without using any crosslinking agent, can realize a reasonable gel forming time, and the gel forming time is less than 10S. At the same time, the gel has a high Viscoelasticity and self-healing properties can better meet the needs of surgical operations.

Description

technical field [0001] The invention belongs to the technical field of biogel materials, and relates to an in-situ glue-forming hydrogel and a preparation method and application thereof. Background technique [0002] In surgical operations, rapid, effective and safe hemostasis is one of the key factors to ensure the success of the operation. How to quickly stop bleeding is an important problem in trauma and surgery. Excessive bleeding will destroy hemodynamics, prolong operation time, and require blood transfusion. Pressing to stop bleeding is the most common and easiest way to stop bleeding, but it is not effective for large, deep and irregular wounds. Hemocompatibility is a very important consideration when using biomaterials for hemostasis. Synthetic hemostats, often made from cyanoacrylates, polyurethanes, and polyethylene glycols, can lead to polymerization and degradation of toxic by-products, solvents, and necrotic tissue that can increase local irritation and infla...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08F220/60C08F230/02A61L24/00
CPCA61L24/00A61L24/001A61L24/0015A61L24/0031A61L2300/404A61L2400/04C08F220/60C08J3/075C08J2333/24C08F230/02
Inventor 王珂高居山赵晓曄
Owner XI AN JIAOTONG UNIV
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