A kind of in-situ colloidal hydrogel and its preparation method and application
An in-situ, glue technology, used in applications, pharmaceutical formulations, surgery, etc., can solve the problem of lack of hemostatic materials, and achieve excellent biocompatibility, rapid gelation time, and mild reaction conditions.
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Embodiment 1
[0030] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1-10%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10-20% and 2-methacryloyl Add 1-3% of oxyethylphosphorylcholine (MPC) into deionized water, add a small amount of APS (0.5%-2%) to the mixed system, shake gently for a few seconds, and quickly form a gel.
[0031] Example 1
[0032] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 5%, (3-acrylamidopropyl) trimethylammonium chloride (AATAC) 15% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.
Embodiment 2
[0034] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 1%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 10% and 2-methacryloyloxyethyl phosphoric acid Choline (MPC) 1% was added to deionized water, a small amount of APS (0.5%) was added to the mixed system, and after a few seconds of gentle shaking, the gel was formed rapidly.
Embodiment 3
[0036] In terms of mass percentage, dimethylaminopropyl acrylamide (DMAPAA) 8%, (3-acrylamidopropyl) trimethyl ammonium chloride (AATAC) 20% and 2-methacryloyloxyethyl phosphoric acid Add 2% choline (MPC) into deionized water, add a small amount of APS (1%) to the mixed system, shake gently for a few seconds and quickly form a gel.
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