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Method for extracting ginkgo flavonoids from ginkgo leaves

A technology of ginkgo flavonoids and ginkgo leaves, which is applied in the direction of medical raw materials, pharmaceutical formulas, and medical preparations containing active ingredients derived from ginkgo biloba. It can solve the problems of long production cycle, low active ingredients, and low extraction rate, and achieve simplification. Production technology, accelerated leaching extraction, and the effect of improving extraction rate

Inactive Publication Date: 2020-06-02
吴双美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the traditional extraction process, the solvent enters the cells easily or faster under heating conditions, but the solubility of soluble substances is higher under hot conditions, and they are dissolved successively, resulting in high osmotic pressure, resulting in low extraction rate and low active ingredients. , and the process is cumbersome and the production cycle is long

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Pre-treatment of ginkgo leaves: dry the dried ginkgo leaves and pulverize them into powder;

[0020] (2) Put the raw material and water into the extraction tank at a ratio of 1:10, and use ultrasonic to extract. The ultrasonic working frequency of ultrasonic extraction is 70KHz, and the extraction time is 25 minutes. Filter, add water to the original volume, and continue ultrasonic extraction for 25 minutes. , filter, and combine the filtrate;

[0021] (3) Concentration under reduced pressure: put the extract into a rotary evaporator to concentrate under reduced pressure, control the temperature at 55°C, control the vacuum degree at 0.1MPa, and concentrate the volume to 1 / 10 of the original volume;

[0022] (4) Enter the macroporous resin for treatment: after filtering the concentrated extract in step (3), directly enter the macroporous resin for treatment;

[0023] (5) Collect the eluate: collect the effluent from the macroporous resin column and the eluate eluted...

Embodiment 2

[0028] (1) Pre-treatment of ginkgo leaves: dry the dried ginkgo leaves and crush them into powder;

[0029] (2) Ultrasonic extraction, put the raw material and methanol with a volume concentration of 75% into the extraction tank at a ratio of 1:10, and use ultrasonic waves for extraction. The ultrasonic working frequency of ultrasonic extraction is 70KHz, and the extraction time is 25 minutes at 25°C. Filter , add methanol to the original volume, continue ultrasonic extraction for 25 minutes, filter, and combine the filtrates;

[0030] (3) Concentration under reduced pressure: put the extract into a rotary evaporator to concentrate under reduced pressure, control the temperature at 45°C, control the vacuum degree at 0.1MPa, and concentrate the volume to 1 / 8 of the original volume;

[0031] (4) Enter the macroporous resin for treatment: after filtering the concentrated extract in step (3), directly enter the macroporous resin for treatment;

[0032] (5) Collect the eluate: col...

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PUM

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Abstract

The invention discloses a method for extracting ginkgo flavonoids from ginkgo leaves. The method comprises the steps: (1) pre-treating the ginkgo leaves; (2) performing extraction with an ultrasonic device; (3) performing concentration under reduced pressure; (4) performing treatment through macroporous resin; (5) collecting an eluate; (6) performing concentration under reduced pressure; (7) detecting an extract; and (8) performing drying and storage on the extract obtained through the steps. The obtained extract has high content of ginkgo flavonoids and ginkgolides, loss of active ingredientscan be avoided, the production process is simplified, the production cycle can be shortened, and meanwhile, the content of ginkgolic acids obtained after treatment is reduced greatly.

Description

technical field [0001] The invention relates to a process for extracting ginkgo leaves, in particular to a method for extracting ginkgo flavonoids from ginkgo leaves. Background technique [0002] Ginkgo biloba (Ginkgo biloba) Ginkgo biloba ) is a unique tree species in my country. Ginkgo biloba contains active ingredients such as flavonoids (about 20 species), terpenes, phenols, beneficial trace elements and 17 amino acids. At present, Ginkgo biloba extract has been developed into medicines, health care products and cosmetics in the United States, Japan, Germany, Italy, Korea and other countries. my country has also set off an upsurge in the development and research of Ginkgo biloba. There are already hundreds of manufacturers producing ginkgo dry extract in China, and ginkgo leaf products have been put into the market one after another. [0003] Ginkgo biloba extract contains a large amount of ginkgo flavonoids and ginkgolides, which can increase cerebral blood flow, imp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16G01N30/02A61K127/00
CPCA61K36/16A61K2236/15A61K2236/33A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/02
Inventor 吴双美
Owner 吴双美
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