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Process for removing heavy metal from ginkgo extract

A technology of Ginkgo biloba extract and heavy metals is applied in the directions of medical raw materials, drug combinations, and plant raw materials derived from Ginkgo biloba, which can solve the problems affecting domestic pharmaceutical safety, residues, and solvents.

Inactive Publication Date: 2020-06-02
吴双美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solvent extraction is very prone to emulsification, which leads to prolonged production time and incomplete extraction. There will be solvent residues in the product, and it is not friendly to operators and the environment.
The patent document "Removal Technology of Ginkgophenolic Acids in Ginkgo Leaf Extract" (CN101194918A) adopts double-column stacking method to remove ginkgolic acid, but the fabrication is more complicated, and the pretreatment and activation of the double-column will produce a certain amount of industrial wastewater
[0004] The excessive content of ginkgolic acid and heavy metals in Ginkgo biloba extract is the bottleneck restricting the export of Ginkgo biloba extract in my country, and also affects the safety of domestic pharmaceuticals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 500g of Ginkgo biloba leaves, add 10, 8 times the amount of 60% ethanol, reflux and extract for 2 hours respectively, filter the medicinal solution, combine them, recover ethanol under reduced pressure until the medicinal solution does not contain alcohol, then add water to 1500ml, let stand, filter, add the filtrate Wash the treated DA201 resin column with pure water. When the effluent is clear, elute with 2000 mL of 80% ethanol, collect the ethanol eluate, add 0.2 g of ferric oxide nanomaterials, ultrasonically adsorb for 2 hours, and put the magnet on The ferric oxide nanometer material is absorbed into the medicinal liquid, the medicinal liquid is concentrated under reduced pressure to recover ethanol, and the extract is vacuum-dried. The iron ferric oxide nanomaterials were collected, soaked in 0.1% hydrochloric acid for 4 hours, magnetically separated, rinsed with deionized water several times, and dried in vacuum for later use. After drying, the Ginkgo bilob...

Embodiment 2

[0025] Take 500g of Ginkgo biloba leaves, add 8 and 6 times the amount of 70% ethanol, reflux and extract for 1.5h respectively, filter the medicinal solution, combine them, recover the ethanol under reduced pressure until the medicinal solution does not contain alcohol, then add water to 1500ml, let stand, filter, and filtrate Add to the treated D101 resin column, clean the column with pure water, when the effluent is clear, elute with 2500mL 80% ethanol, collect the ethanol eluate, and recover the ethanol under reduced pressure until the solid content of the liquid reaches 1.08-1.10 , stop concentrating, add 0.5g of Fe3O4 nanomaterials to the liquid medicine, ultrasonically adsorb for 5 hours, put the electromagnet into the liquid medicine to absorb Fe3O4 nanomaterials, and concentrate the liquid medicine under reduced pressure until the solid content reaches 1.25-1.30 hours , spray-dried. Collect ferric oxide nanomaterials, soak in 1% hydrochloric acid for 2 hours, magnetic...

Embodiment 3

[0027] Take 500g of Ginkgo biloba leaves, add 10, 5 times the amount of 70% ethanol, reflux and extract for 3 hours respectively, filter the medicinal solution, combine, recover ethanol under reduced pressure until the medicinal solution does not contain alcohol, then add water to 1500ml, let stand, filter, add the filtrate Wash the treated AB-8 resin column with pure water. When the effluent is clear, elute with 2000mL 60% ethanol, collect the ethanol eluate, add 1.0g ferric oxide nanomaterial, and ultrasonically adsorb for 8h. The magnet is put into the liquid medicine to absorb the iron ferric oxide nanometer material, the liquid medicine is concentrated under reduced pressure, and when the solid content reaches 1.25-1.30, it is spray-dried. The iron ferric oxide nanomaterials were collected, soaked in 2% hydrochloric acid for 24 hours, magnetically separated, rinsed with deionized water several times, and dried in vacuum for later use. After drying, the Ginkgo biloba extra...

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PUM

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Abstract

The invention discloses a process for removing heavy metal from a ginkgo extract. The process comprises the steps: performing extraction, performing treatment through column chromatography, performingadsorption and separation through a nanomaterial, and performing concentration and drying on the separated liquid so as to obtain a ginkgo leaf extract, wherein the nanomaterial is a ferroferric oxide nanomaterial, and the nanomaterial separation technology is a magnetic separation technology. In terms of improvement, the method also includes the step of recovery of the nanomaterial. The Fe3O4 nanomaterial can be used for adsorbing ginkgolic acid, urushiol, isourushiol and heavy metal, solid-liquid separation is performed through the magnetic separation technology, and the medicine liquid isconcentrated and dried so as to obtain the finished product. The method is environmentally friendly, and has the dual effect of removal of ginkgolic acid and heavy metal.

Description

technical field [0001] The invention belongs to the technical field of natural product preparation, and in particular relates to a method for removing ginkgolic acid and heavy metals in ginkgo biloba extract by using nanomaterial adsorption. Background technique [0002] Ginkgo biloba is the dry leaf of Ginkgo biloba (Ginkgobiloba L.), sweet, bitter, astringent, flat, homecoming, lung meridian, has the effects of astringing the lungs, relieving asthma, promoting blood circulation and removing blood stasis, and relieving pain. It is used for coronary heart disease and angina pectoris. and hyperlipidemia. Ginkgo biloba extract is an extract processed from Ginkgo biloba leaves, which promotes blood circulation, removes blood stasis, and unblocks collaterals. It is used to treat chest pain, stroke, hemiplegia, and speech congestion caused by blood stasis, stable angina pectoris, and cerebral infarction. See above syndrome. Ginkgo biloba and ginkgo leaf extract are used as raw ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P9/10A61P25/00A61K127/00
CPCA61K36/16A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P9/10A61P25/00
Inventor 吴双美
Owner 吴双美
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