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Plungers for drug delivery devices

A delivery device and plunger technology, applied in the field of plungers for drug delivery products, can solve the problems of increasing the contact area between the plunger and the syringe or reservoir, large friction and unpredictability, etc.

Active Publication Date: 2020-06-02
AMGEN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This radial deformation can increase the contact area between the plunger and the syringe or reservoir, resulting in greater friction and unpredictability in the extrusion process

Method used

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  • Plungers for drug delivery devices
  • Plungers for drug delivery devices
  • Plungers for drug delivery devices

Examples

Experimental program
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Embodiment Construction

[0052] Plungers constructed as described herein, also known as plunger stops or stops, provide geometric optimizations that differ from conventional The plunger minimizes friction and variability during use. Additionally, the plunger embodiments described herein minimize the contact area between the plunger and the syringe or container by utilizing ribs rather than cylindrical side contact surfaces, while also maintaining high contact between the ribs and the syringe / reservoir pressure to maintain container closure integrity. Further, the plunger embodiments described herein are configured to have minimal or no increase in contact area under the high loads associated with the delivery of viscous products, i.e., the ribs and the plunger surface extending therebetween during use The center does not expand outward, or expands by a minimal amount to maintain a consistent contact area during use. By some means, the plunger includes three or more radial ribs that maintain a seal w...

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Abstract

A plunger configured as described herein provides geometry optimizations to minimize friction magnitude and variability during use by maintaining low deformation under large extrusion forces. More specifically, plunger embodiments described herein minimize a contact area between the plunger and a syringe or chamber, while also maintaining high contract pressures to maintain container closure integrity. Moreover, the plunger embodiments are configured to have minimal or no increase in the contact area under high loads associated with the delivery of viscous products.

Description

[0001] Cross References to Related Applications [0002] Priority benefit is claimed to U.S. Provisional Patent Application No. 62 / 584,335, filed November 10, 2017, and is expressly incorporated herein by reference in its entirety. technical field [0003] The present disclosure relates generally to plungers, and more particularly to plungers for drug delivery products. Background technique [0004] Highly viscous products are increasingly being used in automatic delivery devices such as auto-injectors and side-injectors. Automatic delivery devices typically have requirements related to the timing of drug delivery. However, when using highly viscous products, automatic delivery devices require a large driving force to achieve the desired drug delivery time. Additionally, automated delivery devices may have drive mechanisms that are spaced from the plunger within the device and deliver up to five times the sustained injection force during the initial impact and throughout d...

Claims

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Application Information

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IPC IPC(8): A61M5/142A61M5/20A61M5/315F16J1/00
CPCA61M5/20A61M2005/2006F16J1/003A61M5/14248A61M5/14244A61M5/31513A61M2005/3117A61M5/2053
Inventor J·贾扎耶里R·福斯特J·塞库特O·A·亨德森K·布朗G·戈登R·赫伦恩西格尔P·D·卡雷索柏格
Owner AMGEN INC