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Medicine application of 20(R)-25-OH-PPD,20(R)-dammarane-3beta,12beta,20,25,-tetrol (AD2)

A dammarane type, hydroxyl technology, applied in the field of medicine, to achieve the effect of inhibiting tachyarrhythmia

Active Publication Date: 2020-06-05
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently about AD 2 Research on arrhythmias has not been reported

Method used

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  • Medicine application of 20(R)-25-OH-PPD,20(R)-dammarane-3beta,12beta,20,25,-tetrol (AD2)
  • Medicine application of 20(R)-25-OH-PPD,20(R)-dammarane-3beta,12beta,20,25,-tetrol (AD2)
  • Medicine application of 20(R)-25-OH-PPD,20(R)-dammarane-3beta,12beta,20,25,-tetrol (AD2)

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0018] The present invention will be further described below in conjunction with specific examples, but the present invention is not limited in any way.

[0019] Experimental material: AD used in this experiment 2 Provided by the School of Functional Food and Wine of Shenyang Pharmaceutical University;

[0020] Wistar rats: purchased from the Experimental Animal Center of Dalian Medical University.

[0021] Experimental equipment: 64-channel electrode (EMS64-USB-1003, MappingLab, USA)

[0022] Constructed model: Isoprenaline (Iso) was used to construct a tachyarrhythmia model. The experimental animals were Wistar rats, whose isolated hearts were perfused, and a 64-channel matrix electrophysiological monitoring system was used to observe AD in real time. 2 Effects on Iso-induced tachyarrhythmia indexes (heart rate, direction of action potential conduction, conduction velocity and electrocardiogram) in isolated rats. The heart was fixed on the Langendorff perfusion device, an...

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Abstract

The invention relates to the technical field of medicine, in particular to application of 20(R)-25-OH-PPD,20(R)-dammarane-3beta,12beta,20,25,-tetrol (AD2) and provides the medicine application of theAD2 in preparation of a medicine for treating and preventing arrhythmia. The AD2 has an inhibition function of rapid arrhythmia.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the medicinal application of 20(R)-25-hydroxyl-dammarane-3β,12β,20-triol. Background technique [0002] Cardiac arrhythmia is one of the most common diseases of the cardiovascular system. It can occur suddenly and cause sudden death, or it can continue to involve the heart and cause it to fail. In recent years, the safety of antiarrhythmic western medicines in clinical application has been continuously questioned. Many medicines have their own limitations and side effects, and have arrhythmogenic effects. Therefore, the unique advantage of pure natural, less toxic and side effects Chinese medicine treatment of arrhythmia has been paid more and more attention by people. [0003] 20(R)-25-Hydroxy-dammarane-3β,12β,20-triol (20(R)-25-OH-PPD,20(R)–dammarane-3β,12β,20,25-tetrol ), referred to as AD 2 , is a new type of protopanaxadiol with high activity newly discovered and extract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P9/06
CPCA61K31/575A61P9/06
Inventor 刘丽萍张庆镐李丹赵余庆曹瑀莹杜丙秀
Owner DALIAN UNIV