Extract of Rheum lhasaense A.J.Li etP.K.Hsiao and application of extract of Rheum lhasaense A.J.Li etP.K.Hsiaoin in preparation of medicine for preventing and/or treating viral pneumonia

A technology of viral pneumonia and extracts, applied in the field of medicine, can solve problems such as unsatisfactory effects, and achieve the effects of reducing the lung index of pneumonia mice caused by coronavirus H1N1, good therapeutic effect, and inhibiting SARS virus

Active Publication Date: 2020-06-05
昆明翔昊科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Viral pneumonia is also commonly used antiviral drugs such as ribavirin, vidarabine and other broad-spectrum antiviral drugs, but the effect is not satisfactory. Viral pneumonia is listed as a common refractory emergency and critical disease in China

Method used

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  • Extract of Rheum lhasaense A.J.Li etP.K.Hsiao and application of extract of Rheum lhasaense A.J.Li etP.K.Hsiaoin in preparation of medicine for preventing and/or treating viral pneumonia
  • Extract of Rheum lhasaense A.J.Li etP.K.Hsiao and application of extract of Rheum lhasaense A.J.Li etP.K.Hsiaoin in preparation of medicine for preventing and/or treating viral pneumonia
  • Extract of Rheum lhasaense A.J.Li etP.K.Hsiao and application of extract of Rheum lhasaense A.J.Li etP.K.Hsiaoin in preparation of medicine for preventing and/or treating viral pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1: the preparation of the total extract of Qu Zha

[0063] (1) Material:

[0064] Quza rhizome: planted in Shangri-La Alpine Botanical Garden, remove impurities, wash, cut into slices or blocks, and dry in the sun. Lot number: 180902, 191003, 190903

[0065] Resin: D101 macroporous adsorption resin, product of Tianjin Haiguang Chemical Co., Ltd., pretreated according to the manufacturer's instructions; 80-100 mesh polyamide resin, product of Zhejiang Huangyan Resin Chemical Co., Ltd., pretreated according to the manufacturer's instructions.

[0066] (2) Preparation method:

[0067] i) Extraction of Quza total extract

[0068] The collected Quza plants are washed with water to remove the soil, hung in a ventilated place to dry, and the underground rhizomes and aboveground stems and leaves are separated, and pulverizers are used to pulverize them into coarse particles.

[0069] Take 100g of underground rhizomes and aboveground stems and leaves, chop them se...

Embodiment 2

[0080] Example 2: Extraction and detection of tristilbene, polydatin, polydatin, picatanol, and resveratrol

[0081] (1) Material:

[0082] Quzha rhizome: Quzha rhizome, purchased in Lhasa, Tibet, removed impurities, washed, cut into slices or blocks, and dried in the sun. Batch number: 190903

[0083] (2) Preparation of Quza total extract

[0084] Using 75% ethanol as the extraction solvent, the total extract of Quzha was prepared according to the steps described in Example 1.

[0085] (3) Purification and extraction of resveratrol, polydatin, and picetanol

[0086] 200 grams of Quza total extract, heated and dissolved in 200 mL of water, left for 12 hours, centrifuged at 5000 rpm for 10 minutes, dissolved in 50 mL of 45% ethanol for centrifugal precipitation, decolorized with 2 grams of activated carbon at 80°C for 15 minutes, suction filtered while hot, and the filtrate 4 Place at ℃ for 4 hours for crystallization, and vacuum-dry the crystals to obtain 62 g of white nee...

Embodiment 3

[0096] Example 3: Preparation of Quzha Extract Samples 1-16

[0097] Mix the substances in the following table to obtain Quzha extract samples 1-16, calculated by weight percentage.

[0098]

[0099]

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PUM

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Abstract

The invention discloses an extract of Rheum lhasaense A.J.Li etP.K.Hsiao and application of the extract of Rheum lhasaense A.J.Li etP.K.Hsiaoin in preparation of a medicine for preventing and / or treating viral pneumonia. The effective ingredients of the extract of Rheum lhasaense A.J.Li etP.K.Hsiao are toluylene substances which mainly are piceatannol3'-O-glucoside, polydatin, methyl polydatin, piceatannol and resveratrol. The extract has various pharmacological activities such as antiviral, antibacterial, anti-inflammatory, and scavenging free radicals, can significantly reduce the lung indexof coronavirus-infected mice, is anti-shock, and can be used to prepare pharmaceutical preparations for preventing and treating viral pneumonia.

Description

technical field [0001] The application relates to a Quza extract and its application in the preparation of drugs for the prevention and / or treatment of viral pneumonia, which belongs to the field of medicine. Background technique [0002] Viral pneumonia is highly contagious, and the elderly, infants, and those with weak constitutions and low immunity are susceptible to infection. Pneumonia can cause lung tissue necrosis and lead to lung abscess, and lung infection can also cause various specific complications. If the infection can spread to the pleural cavity, it can cause empyema, and hematogenous dissemination can also lead to pleurisy, endocarditis, pericardial Inflammation, arthritis etc. [0003] Severe pneumonia can sustain high fever, palpitations, shortness of breath, dyspnea, and may even be accompanied by shock, respiratory failure, respiratory distress syndrome, and multiple organ failure. [0004] In recent years, coronaviruses (Coronaviridae) with tropism of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K31/7034A61K31/05A61P11/00A61P31/12A61P31/14A61P31/16A61P31/04A61P39/06A61K125/00
CPCA61K36/708A61K31/7034A61K31/05A61P11/00A61P31/12A61P31/14A61P31/16A61P31/04A61P39/06
Inventor 胡琳任杨帆李清清胡群尹开云方震东
Owner 昆明翔昊科技有限公司
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