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Ultra-early liver cancer screening and evaluating product based on saliva specific glycoprotein sugar chain structure and application

An early-stage liver cancer and glycoprotein technology, which is applied in the products and application fields of ultra-early liver cancer screening and evaluation based on the saliva-specific glycoprotein sugar chain structure, can solve problems such as abundance differences

Pending Publication Date: 2020-06-05
深圳格道糖生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And there is also a significant difference in the abundance of the same protein between serum and saliva

Method used

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  • Ultra-early liver cancer screening and evaluating product based on saliva specific glycoprotein sugar chain structure and application
  • Ultra-early liver cancer screening and evaluating product based on saliva specific glycoprotein sugar chain structure and application
  • Ultra-early liver cancer screening and evaluating product based on saliva specific glycoprotein sugar chain structure and application

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Experimental program
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Embodiment Construction

[0056] Such as figure 1 As shown, previous studies have found that there is an obvious overlapping area between patients with liver cirrhosis and patients with liver cancer, and the patients with liver cirrhosis in the overlapping area are either considered to be patients with a high probability of cancer or have undergone malignant transformation. Therefore, it is defined as ultra-early stage liver cancer (UE-HCC). Further analysis found that the relative abundance of sugar chains recognized by MAL-I (Gal / GalNAcβ-1, 4GlcNAc, Siaα2-3Gal, Gal / GalNAcβ1-3GlcNAc, Siaα2-3) was significantly different between HC and UE-HCC groups. difference. Based on this, we designed and completed the following experiments.

[0057] The relevant verification experiments and analysis of the present application are introduced in detail below, and the inventor's specific research and development process is not limited thereto.

[0058] 1. Research methods:

[0059] A lectin magnetic particle comp...

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Abstract

The invention discloses an ultra-early liver cancer related screening and evaluating product based on a saliva specific glycoprotein sugar chain structure and application. Aiming at a saliva sample, aproduct for screening, early diagnosis, risk assessment, drug screening and / or curative effect assessment of the ultra-early liver cancer is provided, whether the saliva sample contains any one or any combination of specific 26 N-sugar chains or not is detected, and whether a saliva sample main body is an ultra-early liver cancer patient (not a liver cirrhosis patient) or not can be judged. Correspondingly, lectin playing a role in specific binding recognition is MAL-I and can be independently used as a reagent for recognizing a saliva specific glycoprotein sugar chain structure to be used for preparing related medical products.

Description

technical field [0001] The invention relates to the determination of an ultra-early liver cancer marker based on saliva-specific glycoprotein and related products and applications. Background technique [0002] Hepatic carcinoma (HCC) is a malignant tumor of the liver. Primary liver malignant tumors originate from the epithelial or mesenchymal tissues of the liver. Cirrhosis can progress to liver cancer if left untreated. Due to the insidious onset of liver cancer, no symptoms or no obvious symptoms in the early stage, and the rapid development of liver cancer, the diagnosis is that most patients have reached locally advanced or distant metastasis. Therefore, treatment is difficult and the prognosis is poor. my country is a high prevalence area of ​​chronic hepatitis, especially hepatitis B. About 120 million people have been carrying hepatitis B (Hepatitis B, HB) virus for a long time, and there are about 30 million chronic hepatitis patients. About 300,000 chronic hepati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G16H50/20
CPCG01N33/57438G01N33/57488G16H50/20
Inventor 李铮于汉杰
Owner 深圳格道糖生物技术有限公司
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