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Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells
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A technology of microorganisms and cells, applied in the field of modified microorganisms, can solve problems such as adverse events of undesired autoimmune responses
Pending Publication Date: 2020-06-05
SYNLOGIC OPERATING CO INC
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As a result, many current immunotherapies suffer from toxicity due to high dose requirements and also often lead to undesired autoimmune responses or other immune-related adverse events
[0007] Therefore, effective cancer treatments exist that can target poorly vascularized hypoxic tumor regions, specifically target cancer cells, while minimally affecting normal tissues, and boost the immune system to fight tumors, including avoiding or reversing tumor immune tolerance. unmet needs
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[0173] Certain tumors are particularly difficult to control with conventional therapies. Hypoxia is a characteristic feature of solid tumors in which cancer cells exist at very low oxygen concentrations. The hypoxic area often surrounds necrotic tissue and as a solid form of cancer grows too large for its vasculature. When the vascular supply fails to meet the metabolic demands of the tumor, the tumor microenvironment becomes hypoxic. Multiple regions within tumors contain <1% oxygen compared to 3-15% in normal tissue (Vaupel and Hockel, 1995), and avascular regions can constitute 25-75% of tumor mass (Dang et al., 2001 ). Approximately 95% of tumors are hypoxic to some extent (Huang et al., 2004). Systemically delivered anticancer agents rely on tumor vasculature for delivery; however, poor vascularization hinders oxygen supply to rapidly dividing cells, making them useful for targeting cell proliferation in poorly vascularized hypoxic tumor regions. Therapeutics are less...
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Abstract
Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
Description
[0001] related application [0002] This application claims U.S. Provisional Application No. 62 / 531,784 filed on July 12, 2017; U.S. Provisional Application No. 62 / 543,322 filed on Aug. 9, 2017; U.S. Provisional Application No. 62 / 552,319 filed on Aug. 30, 2017 ; U.S. Provisional Application No. 62 / 592,317 filed on November 29, 2017; U.S. Provisional Application No. 62 / 607,210 filed on December 18, 2017; PCT Application No. PCT / US2018 / 012698 filed on January 05, 2018; U.S. Provisional Application No. 62 / 628,786, filed February 9, 2018; U.S. Provisional Application No. 62 / 642,535, filed March 13, 2018; U.S. Provisional Application No. 62 / 657,487, filed April 13, 2018; and 2018 Priority to U.S. Provisional Application No. 62 / 688,852, filed June 22. The entire contents of each of the aforementioned applications are expressly incorporated herein by reference. [0003] sequence listing [0004] This application contains a Sequence Listing, which has been filed electronically in...
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