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Application of reagent for detecting flora in preparation of reagent or kit for prognosis prediction markers of esophageal squamous cell carcinoma patients

A technology for esophageal squamous cell carcinoma and markers, applied in reagents or kits, in the field of reagents for detecting bacterial flora, can solve problems such as single identification indicators, insufficient representation, and unconsidered

Active Publication Date: 2020-06-12
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the prognostic analysis is only carried out for a certain specific bacteria, without considering the influence of other bacteria in the tissue, and there are problems of single identification index and insufficient representativeness.

Method used

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  • Application of reagent for detecting flora in preparation of reagent or kit for prognosis prediction markers of esophageal squamous cell carcinoma patients
  • Application of reagent for detecting flora in preparation of reagent or kit for prognosis prediction markers of esophageal squamous cell carcinoma patients
  • Application of reagent for detecting flora in preparation of reagent or kit for prognosis prediction markers of esophageal squamous cell carcinoma patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. For the flow chart, see figure 1 .

[0050] 2. Operation steps

[0051] 1. Screening of patients with esophageal squamous cell carcinoma

[0052] A total of 120 patients with esophageal squamous cell carcinoma who were treated in Fujian Cancer Hospital and Zhangzhou Hospital in Fujian Province from February 2013 to October 2017 were selected. Inclusion criteria: radical surgery for esophageal cancer; all subjects were diagnosed with esophageal squamous cell carcinoma by surgical pathology; no radiotherapy or chemotherapy was received before surgery; no antibiotic use record 2 months before surgery; no other infectious disease. Exclusion criteria: patients with incomplete clinical and pathological data and tissue samples; patients with metastatic tumors and recurrence of esophageal cancer; patients with severe heart and brain organic diseases and mental illness history.

[0053] 2. Method

[0054] 2.1 Tissue sample collection

[0055] The cancer tissues of each ...

Embodiment 2

[0106] 1. For the flow chart, see Figure 7 .

[0107] 2. Operation steps

[0108] 1. Screening of patients with esophageal squamous cell carcinoma

[0109] A total of 120 patients with esophageal squamous cell carcinoma who were treated in Fujian Cancer Hospital and Zhangzhou Hospital in Fujian Province from February 2013 to October 2017 were selected. Inclusion criteria: radical surgery for esophageal cancer; all subjects were diagnosed with esophageal squamous cell carcinoma by surgical pathology; no radiotherapy or chemotherapy was received before surgery; no antibiotic use record 2 months before surgery; no other infectious disease. Exclusion criteria: patients with incomplete clinical and pathological data and tissue samples; patients with metastatic tumors and recurrence of esophageal cancer; patients with severe heart and brain organic diseases and mental illness history.

[0110] 2. Method

[0111] 2.1 Tissue sample collection

[0112] The paracancerous tissues ...

Embodiment 3

[0162] 1. For the flow chart, see Figure 12 .

[0163] 2. Treatment groups

[0164] The subjects were divided into two groups, surgery group, surgery + postoperative chemotherapy (platinum + paclitaxel) group.

[0165] 3. Operation steps

[0166] 1. Screening of patients with esophageal squamous cell carcinoma

[0167] A total of 120 patients with esophageal squamous cell carcinoma who were treated in Fujian Cancer Hospital and Zhangzhou Hospital in Fujian Province from February 2013 to October 2017 were selected. Inclusion criteria: radical surgery for esophageal cancer; all subjects were diagnosed with esophageal squamous cell carcinoma by surgical pathology; no radiotherapy or chemotherapy was received before surgery; no antibiotic use record 2 months before surgery; no other infectious disease. Exclusion criteria: patients with incomplete clinical and pathological data and tissue samples; patients with metastatic tumors and recurrence of esophageal cancer; patients w...

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Abstract

The invention provides application of a reagent for detecting flora in preparation of a reagent or a kit for prognosis prediction markers of esophageal squamous cell carcinoma patients, and belongs tothe technical field of prognosis detection of esophageal squamous cell carcinoma. In the present invention, the flora comprises one or multiple selected from Cronobacter in cancer tissues of patientswith esophageal squamous cell carcinoma, Family Halomonadaceae in para-carcinoma tissue of esophageal squamous cell carcinoma patients, and Carnobacterium in para-carcinoma tissue of esophageal squamous cell carcinoma patients. According to the invention, microorganism-related evidences are provided for prognosis prediction of esophageal squamous cell carcinoma, and a reference basis is providedfor prognosis prediction of esophageal squamous cell carcinoma patients.

Description

technical field [0001] The invention relates to the technical field of prognosis detection of esophageal squamous cell carcinoma, in particular to the application of reagents for detecting flora in the preparation of reagents or kits for prognostic markers for patients with esophageal squamous cell carcinoma. Background technique [0002] Esophageal cancer is one of the most common malignant tumors that seriously endanger people's health in China. 95% of them are esophageal squamous cell carcinomas. It has the characteristics of high malignancy, rapid metastasis, poor postoperative quality of life, and obvious regional incidence. [0003] In the prior art, Gao et al. used qPCR sequencing technology to detect the distribution of cancer tissue flora in patients with esophageal squamous cell carcinoma, and found that Porphyromonas gingivalis was more abundant in cancer tissues, and Porphyromonas gingivalis Factors affecting the prognosis of patients with squamous cell carcinoma...

Claims

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Application Information

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IPC IPC(8): C12Q1/04C12R1/01
CPCC12Q1/04G01N2800/52G01N2800/7028Y02A50/30
Inventor 胡志坚林征刘双相智声谢倩雯
Owner FUJIAN MEDICAL UNIV
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