Application of granulocyte group basophils as diagnostic markers for allergic diseases

Abstract

The invention relates to the field of medical diagnostics, and in particular relates to an application of granulocyte group basophils as diagnostic markers for allergic diseases. The inventors classify basophils into mononuclear cell group basophils and the granulocyte group basophils, and conduct a systematic study on the granulocyte group basophils to find that the granulocyte group basophils are specifically associated with the allergic diseases and can be used for the diagnosis of the allergic diseases. The diagnostic method has good specificity and easy detection, and is easy to promote and clinically apply.

Description

technical field [0001] The invention relates to the field of medical diagnostics, in particular to the application of granulocyte group basophils as diagnostic markers for allergic diseases. Background technique [0002] The incidence of allergic (allergic) disease accounts for more than 30% of the world's total population, and is listed as one of the four major non-infectious diseases in the 21st century by the World Health Organization. With the development of industrial economy and the change of ecological environment, such diseases have been increasing in recent years, becoming common and frequently-occurring diseases, which is a major problem that needs to be solved in the field of health and economic development in our country. [0003] But so far, the problem of laboratory qualitative diagnosis of allergic diseases has not been solved, and the problem of "false negative" often occurs clinically, that is, the doctor tells the patient that he (she) is not allergic becau...

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Problems solved by technology

[0003] But so far, the problem of laboratory qualitative diagnosis of allergic diseases has not been solved, and the problem of "false negative" often occurs clinically, that is, the doctor tells the patient that he (she) is not allergic because he (she) cannot find the allergen of the patient

The reasons mainly include the following aspects: (1) There are thousands of allergens, but there are only dozens of commonly used clinically, so if the patient's allergens are not included in these dozens, it will be " (2) The quality of current allergen preparations is low. There is no standardized allergen in Asia including my country, and Europe and the United States only use the first generation of standardized allergen preparations defined more than 20 years ago.

Since the first generation of standardized allergen preparations only has 24 species, and even the first generation of standardized allergen preparations only monitors one of the main allergens (allergy that can induce allergic reactions in more than 50% of patients allergic to this species) Original protein), so for species known to contain about 10 major allergens, such as mites, cockroaches, peanuts, etc., even if its first-generation standardized allergen preparations are used, there is still a problem because the preparations do not contain triggers. The problem of "missed diagnosis" caused by the specific allergen protein of allergy

For example, a patient with house dust mite allergy is only allergic to Der p21, the main allergen of house dust mite, but not to Der p1 monitored in the preparation, so a negative result of mite test occurs clinically, making the doctor mistakenly believe that the patient is allergic to house dust mite (3) Clinically, there is a lack of a method that can "qualify" allergic diseases, that is, first determine whether the patient is allergic, and then screen the patient for allergens (such as skin prick test, Allergen-specific IgE detection, etc.), to determine which allergen-induced allergies the patient is allergic to

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