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Medicine for treating inflammatory bowel diseases

An inflammatory bowel disease and drug technology, applied in the direction of drug combination, medical raw materials derived from mammals, antipyretics, etc., can solve the problem of no inflammatory bowel disease cellular immunotherapy method, etc.

Active Publication Date: 2020-07-07
THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no prior art on cellular immunotherapy for the treatment of inflammatory bowel disease

Method used

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  • Medicine for treating inflammatory bowel diseases
  • Medicine for treating inflammatory bowel diseases
  • Medicine for treating inflammatory bowel diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Using mice as a model to establish a method for DN T cells used in immunotherapy for inflammatory bowel disease

[0022] 1. The establishment process of IBD mouse model

[0023] Using dextran sulfate sodium (DSS) to induce the colitis model in mice, the mice were given water containing 3% (w / v) DSS for 7 days, and then changed to normal water for 1 day to construct mice Colitis model. The body weight and disease activity index (DAI) of mice were detected daily to evaluate the severity of colitis in mice. DAI score includes stool properties, rectal bleeding, etc.

[0024] 2. Reinfusion of DN T cells into the established mouse model

[0025] The method of DN T cells for immunotherapy of inflammatory bowel disease uses the following components: (1) specific fluorescent antibody for T cells; (2) medium (1640 medium with 10% fetal bovine serum); (3) Interleukin-2 (20ng / ml).

[0026] Specifically include the following steps:

[0027] S1. Take 20ml of periphera...

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PUM

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Abstract

The invention belongs to the technical field of immunization therapy, and discloses a medicine for treating inflammatory bowel diseases. The medicine comprises CD4-CD8- dual feminine T cells. Throughsteps of constructing a mouse model suffering from the inflammatory bowel diseases, then extracting self peripheral blood, separating DN T cells, performing ex vivo expansion culture, and performing intravenous injection and reimportation to self, the purpose of relieving and treating intestinal tract inflammation can be achieved. According to the medicine disclosed by the invention, the DN T cells and an immunization therapy method are utilized for the first time, so that immunization therapy of the inflammatory bowel diseases can be realized, and the method has the advantages of alleviatingthe intestinal tract inflammation and the like, is suitable for comprehensive therapy of the inflammatory bowel diseases and is suitable for clinical promotion and application.

Description

technical field [0001] The present invention specifically relates to the technical field of immunotherapy, and more specifically, to medicines for treating inflammatory bowel disease. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is an autoimmune disease, which is a chronic idiopathic disease that occurs in the intestinal tract, requires life-long treatment and is incurable, with clinical characteristics of frequent relapses and remissions. In the past ten years, the number of patients with IBD in my country has gradually increased, and it will become a common disease of the digestive system in my country. Conventional drug therapies for IBD, such as anti-inflammatory agents, glucocorticoids, and immunosuppressants, are limited due to their systemic adverse effects and toxicity during long-term treatment. [0003] Cell therapy is to activate and expand autologous or allogeneic immune effector cells in vitro, and then infuse them ...

Claims

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Application Information

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IPC IPC(8): A61K35/17A61P1/00A61P29/00
CPCA61K35/17A61P1/00A61P29/00
Inventor 黄曦王子晴洪海吴永坚
Owner THE FIFTH AFFILIATED HOSPITAL SUN YAT SEN UNIV
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