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A kind of preparation method of guanidinoacetic acid

A technology of guanidinoacetic acid and guanidinoacetic acid, which is applied in the field of guanidinoacetic acid preparation, can solve the problems of low utilization rate of raw materials glycine and cyanamide, increased difficulty of purification of crude guanidinoacetic acid, and increased cost of guanidinoacetic acid, etc. Achieve high raw material utilization rate, reduce the difficulty of purification process, and reduce the effect of preparation cost

Active Publication Date: 2022-05-31
内蒙古天翊生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (1) Many side reactions lead to many by-products in guanidinoacetic acid, which increases the difficulty of purifying the crude product of guanidinoacetic acid on the one hand, and causes low utilization of raw materials glycine and cyanamide on the other hand, which increases the yield of guanidinoacetic acid. Increased costs
[0006] (2) In the process of purifying the crude product of guanidinoacetic acid, the purification process is not only complicated, but also the solvent used in the purification process is very harmful to the environment and human body.

Method used

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  • A kind of preparation method of guanidinoacetic acid

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Step 1: 50 g of gram ethanolamine and 20 g of water were added to the reactor, and the temperature was raised to 40 °C with stirring.

Embodiment 2

[0042] Step 1: 50 g of gram ethanolamine and 50 g of water were added to the reactor, and the temperature was raised to 70 °C with stirring.

Embodiment 3

[0049] Step 1: 50g of gram ethanolamine and 35g of water were added to the reactor, and the temperature was raised to 50°C with stirring.

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Abstract

The invention discloses a preparation method of guanidinoacetic acid. The present invention selects ethanolamine and cyanamide as raw materials for the preparation of guanidinoacetic acid, firstly obtains guanidinoethanol through the reaction of ethanolamine and cyanamide, and then uses TEMPO to obtain the guanidinoethanol Carry out catalysis to obtain the crude product of guanidinoacetic acid, and then use ethanol to purify the crude product of guanidinoacetic acid to obtain the fine product of guanidinoacetic acid. In the preparation method of guanidinoacetic acid of the present invention, there is almost no side reaction in the preparation process of guanidinoacetic acid, thereby reducing the generation of by-products in the preparation process of guanidinoacetic acid, and reducing the difficulty of the purification process of crude guanidinoacetic acid. Simultaneously, since there is basically no side reaction in the whole reaction process, the utilization rate of raw materials is improved, the preparation cost of guanidinoacetic acid is reduced, and the purity of guanidinoacetic acid prepared by the method is also high.

Description

A kind of preparation method of guanidinoacetic acid technical field The present invention is specifically related to a kind of preparation method of guanidinoacetic acid. Background technique [0002] Guanidinoacetic acid is a white or slightly yellow crystalline powder, soluble in water, and very slightly soluble in ethanol and ether. guanidinoacetic acid Mainly used in pharmaceutical organic synthesis intermediates, but also as food and feed additives, to improve production performance, improve meat quality and It plays an important role in promoting energy metabolism, etc. In addition, it can prevent bacterial infection, enhance animal immune function, and reduce fever. The effects of stress on animals, thereby reducing animal mortality in high temperature environments. According to relevant literature report, the main production technique of guanidinoacetic acid is: thiourea, bromoethane and dehydrated alcohol are mixed, in water The bath was warmed for 3h to c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C277/08C07C279/08C07C279/14
CPCC07C277/08C07C279/08C07C279/14Y02P20/584
Inventor 王磊
Owner 内蒙古天翊生物科技有限公司