44 results about "Glycocyamine" patented technology

The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

The invention discloses a chemical synthesis method of glycocyamine. The method comprises the following steps: 1. adding isopropanol, glycine and 10% of sodium hydroxide solution to a reactor and stirring the materials at room temperature until the materials are dissolved to obtain alkaline mixed solution; 2. dropwise adding cyanamide solution to the alkaline mixed solution, then carrying out stirring and reflex at certain temperature for a while, carrying out concentration under reduced pressure after reaction to vaporize a solvent to obtain the crude product of glycocyamine; and 3. throwing the crude product of guanidinobenzoic acid and water into the reactor, raising the temperature and stirring the materials and then carrying out leaching, washing and drying, thus finally obtaining glycocyamine. The chemical synthesis method provided by the invention is more suitable for industrial scale production.

Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine.

The invention provides a growth-promoting feed additive capable of improving the lean meat rate of a growing-finishing pig. The growth-promoting feed additive comprises the following components in parts by weight: 0.5-1.2 parts of nanometer-level NMDA (N-methyl-D-aspartate), 1.5-2.5 parts of glycine betaine, 7-10 parts of glycocyamine, 1-1.5 parts of Enviva EO, 40-50 parts of radix scutellariae, 20-30 parts of purslane and 15-20 parts of pine needles. The growth-promoting feed additive provided by the invention is green, healthy and pollution-free without containing antibiotics and can reduce the usage of the antibiotics, enhance the growth property of the growing-finishing pig, improve the meat quality and enhance the lean meat rate through the addition of Chinese medicinal herbs and growth-promoting regulators.

The invention belongs to the technical field of breeding, and discloses a composition of guanidinoacetic acid and a synergist thereof, a preparation method and application. The composition of the guanidinoacetic acid and the synergist thereof is prepared by uniformly mixing guanidinoacetic acid, carbohydrates, sodium chloride and methyl donor, and can be added to daily ration for feeding animals.The guanidinoacetic acid and the methyl donor are added to promote creatine synthesis, and carbohydrates and sodium chloride are supplemented to increase creatine absorption of muscle tissues, so thatmuscle protein deposition is promoted, and the problem that the production performance of livestock and poultry is reduced under an antibiotic-free condition is solved. The composition of the guanidinoacetic acid and the synergist thereof is suitable for being added into daily ration to feed animals.

The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, guanidino benzoates as energy generating systems and antioxidants for preservation of skin against adverse aging effects and damage secondary to insults such as harmful sun radiations, stress and fatigue. The creatine compounds which can be used in the present method include (1) creatine, creatine phosphate and analogs of these compounds which can act as substrates or substrate analogs for creatine kinase; (2) molecules that mimic the biological activity of creatine (3) molecules that modulate the creatine kinase system.

The invention provides 4-percent premixed mutton sheep feed, and relates to the technical field of animal feed. The 4-percent premixed mutton sheep feed is prepared from the following ingredients in parts by weight: 31.25 parts of mutton sheep polymineral, 5 parts of mutton sheep multivitamin, 3.83 percent of 98-percent glycocyamine, 5 parts of 50-percent garlicin, 3.75 parts of 10-percent salinomycin sodium, 1.9 parts of 66-percent ethoxyquin, 86.78 parts of zeolite, 150 parts of calcium hydrophosphate, 125 parts of mountain flour, 87.5 parts of common salt, 15 parts of mulberry leaf powder, 20 parts of carrot seedlings, 15 parts of sweet potato leaf powder, 20 parts of peanut shell powder, 15 parts of locust tree powder, 2 parts of honey and 6 parts of traditional Chinese medicine additives. Compared with traditional feed, the 4-percent premixed mutton sheep feed provided by the invention has the advantages that traditional Chinese medicine ingredients are contained in the premixed feed; the traditional Chinese medicine additives and feed carriers cooperate with each other to take effects; the normal nutritional requirements of mutton sheep are ensured; in addition, the disease prevention and the disease treatment can be achieved; the immunity of the mutton sheep can be improved; in addition, the growth of the mutton sheep can also be promoted; no toxic or side effect exists; drug resistance is not generated; the environment is not polluted; the body resistance can be enhanced; the effects are fast; and the price is low.

The invention discloses an anti-stress agent for relieving transportation stress before fowl slaughtering, and a preparation method thereof. The anti-stress agent is prepared from the components in percentage by weight: 20 to 50 percent of glucose, 5 to 20 percent of guanidinoacetic acid glycine, 5 to 20 percent of glutamine, 5 to 13 percent of theanine, 5 to 10 percent of glycine betaine, 5 to 10percent of L-ascorbic acid, 1 to 5 percent of tannin, 1 to 4 percent of potassium citrate, 0 to 5 percent of sodium propionate, 0 to 5 percent of sodium diacetate, 0 to 5 percent of lactic acid, 1 to3 percent of potassium chloride, and 0 to 2 percent of sodium bicarbonate. 0.01 to 3 percent by weight of anti-stress agent is added into drinking water for fowl. The fowl drinks the anti-stress agent 48 hours before being loaded and 2 hours after being unloaded, and does not drink during the transportation process. After the fowl drinks the anti-stress agent, the moisture content of chicken canbe remarkably improved, the comprehensive stress reaction before slaughtering is reduced, the weight loss is reduced, and the economic loss is reduced.

The invention relates to an additive feed for fattening beef cattle and a use method of the additive feed. The additive feed is prepared from the following components in parts by weight: 0.05-0.2 parts of Vitamin A, 0.03-0.1 parts of vitamin D3, 0.5-1.5 parts of vitamin E, 0.5-1 part of vitamin B1, 10-15 parts of guanidinoacetic acid, 3-8 parts of glycine betaine, 0.05-0.2 parts of selenomethionine, 0.5-1 part of rumen bypass choline, 1-2 parts of ferroporphyrin, 2-5 parts of zinc sulfate, 15-20 parts of magnesium oxide, 20-30 parts of sodium sulfate, 10-18 parts of hay vinasse, 2-5 parts of potassium chloride, 1-3 parts of clostridium butyricum, 0.1-0.5 parts of an antioxidant and 20-30 parts of rice hull powder. The additive feed has the effects of promoting the rumen health of cattle and increasing the lean meat percentage of beef cattle.

The invention discloses a genetically engineered bacterium for producing guanidinoacetic acid as well as a construction method and an application of the genetically engineered bacterium. The inventionprovides the construction method of guanidinoacetic acid-producing engineering bacteria, which comprises the following steps: introducing guanidinoacetic acid synthesis-related gene L-arginine: glycine amidinyl transferase encoding gene into host bacteria to obtain guanidinoacetic acid-producing engineering bacteria; wherein the host bacteria are escherichia coli or mutant escherichia coli. According to the invention, an AGAT catalytic reaction which does not exist in the background is constructed in escherichia coli by a method of expressing foreign protein. Meanwhile, by means of plasmid overexpression of protein, replacement of promoters on chromosomes, gene knockout and the like, the flow of an ornithine circulating metabolic pathway of escherichia coli is increased, inhibition of ornithine on AGAT catalytic reaction is relieved, arginine is recycled through a whole-cell catalysis method to produce guanidinoacetic acid, and good environmental and economic prospects are achieved.

The invention provides fortified pig compound feed capable of reducing backfat thickness and belongs to the field of feed. The fortified pig compound feed comprises, by weight, 45-55 parts of corn, 0-20 parts of barley, 18-25 parts of soybean meal, 0-12 parts of wheat middling, 5-10 parts of rice bran, 0-8 parts of corn germ meal, 5-7 parts of premix, 0.5-1.2 parts of essential amino-acid, 0.035-0.065 part of cysteamine and 0.025-0.065 part of guanidinoacetic acid. The fortified pig compound feed has the advantages that the content of lysine, methionine, threonine and tryptophan in the feed is increased, the lysine, methionine, threonine and tryptophan are compounded with the cysteamine and guanidinoacetic acid, pig lean meat growth potential is brought into full play, pig body type is further optimized, fat meat deposition is reduced, and low feed conversion ratio is achieved.

The present invention pertains to a process for preparing guanidino acetic acid (GAA) from cyanamide and glycine in alkaline process solution, in which anionic impurities are removed from the process solution by electrodialysis.

The invention discloses a functional feed additive for micropterus salmoides with functions of food calling and digestion promoting and effects of remarkably reducing body fat and liver fat and improving fish body immunity. The feed additive comprises the following components in percentage by weight: 7.0% of dimethyl-beta-propiothetin (DMPT) hydrochloride, 6.0% of allicin, 10.0% of L-valine, 7.0% of betaine hydrochloride, 8.5% of guanidinoacetic acid, 16.0% of lysophosphatide powder, 5.0% of L-carnitine hydrochloride, 17.0% of an eucommia ulmoides extract and the balance carrier zeolite powder. According to the application method, in the production process, 0.3-0.9% of the additive is added into each ton of micropterus salmoides compound feed. All the components of the feed additive are natural green products, and the feed additive is stable in quality, non-toxic, harmless, free of residues, low in addition amount and easy to popularize.

The invention relates to a method for refining glycocyamine. The method comprises the steps as follows: A. certain quantity of crude glycocyamine is dispersed in water to prepare turbid glycocyamine solution; B. certain quantity of sodium hyposulfite is dissolved in the water to prepare sodium hyposulfite aqueous solution; C. the sodium hyposulfite aqueous solution obtained in step B is dropwise added into the turbid glycocyamine solution obtained in step A and simultaneously the turbid glycocyamine solution is stirred and heated to react for a period of time; D. mixed solution obtained in step C is cooled and filtered to collect solid substance; and E. the solid substance obtained in step D is dried to obtain a refined glycocyamine product. The method for refining the glycocyamine can prepare the refined glycocyamine product with the purity more than 99 percent.

The present invention discloses a method for synthesizing glycocyamine and salt thereof. The method for synthesizing glycocyamine salt comprises the following steps: 1) carrying out neutralization reaction on guanidine hydrochloride and an alkaline matter C for obtaining solution A; 2) facilitating chloroacetic acid to react with alkaline solution for obtaining solution B; and 3) facilitating thesolution A to react with the solution B for generating glycocyamine salt. The alkaline matter C can be sodium hydroxide or sodium carbonate. Preferably the mass ratio of sodium hydroxide:guanidine hydrochloride:chloroacetic acid is 200:480:460. Preferably the mass ratio of sodium carbonate:guanidine hydrochloride:chloroacetic acid is 265:480:460. Preferably the reacting temperature of step 3) is 40 DEG C. The holding time of reaction is no less than 24 hours. The synthesis of glycocyamine refers to that the solution of step 1) directly reacts with the chloroacetic acid. The method used by theinvention has the advantages of simple synthetic process, convenient operation, higher yield, less byproducts and convenient separation and purification. The product purity of the compound of the invention can be higher than 98%.