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Pharmaceutical composition for preventing and treating hypotension in dialysis and preparation method of pharmaceutical composition

A composition and technology for low blood pressure, applied in the directions of drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of not improving the prognosis and quality of life of patients, increasing the workload of medical staff, and reducing the quality of hemodialysis. , to achieve the effect of improving microcirculation, significant curative effect, reducing and hypotension during dialysis

Pending Publication Date: 2020-07-17
邱模炎 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these measures can improve the occurrence or progress of hypotension in dialysis to a certain extent, they also increase the cost of hemodialysis, reduce the quality of hemodialysis, seriously increase the workload of medical staff, and cannot improve the prognosis and quality of life of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] This example provides a traditional Chinese medicine composition for preventing and treating hypotension in hemodialysis, including the following materials by weight: 2 parts of total ginsenosides, and 4.5 parts of total lignans from Schisandra chinensis.

[0025] The extraction method of described ginsenosides comprises the following steps:

[0026] 1) Ginseng crude drug, add 95% ethanol, reflux extraction 3 times, 2 hours each time. Combine 3 alcohol extracts, filter and concentrate to a paste, add appropriate amount of distilled water to dissolve. The resulting solution was defatted three times with ether, extracted five times with n-butanol, and the extracts were combined. N-butanol was recovered under reduced pressure, the residue was dissolved in distilled water, and the pH value was adjusted to 7 with sodium hydroxide to obtain a ginseng extract.

[0027] 2) Use X-5 macroporous adsorption resin, the condition is that the mass concentration of the sample solutio...

Embodiment 2

[0035] This example provides a traditional Chinese medicine composition for preventing and treating hypotension in hemodialysis, including the following materials by weight: 1 part of total ginsenosides, and 1.5 parts of total lignans from Schisandra chinensis.

[0036] The preparation method of the total ginsenosides and the total lignans of Schisandra chinensis is the same as that in Example 1.

[0037] The preparation method of the pharmaceutical composition for preventing and treating hypotension in dialysis comprises the following steps: uniformly mixing 1 part of total ginsenosides and 1.5 parts of total lignans of schisandra chinensis of the above raw materials, adding appropriate amount of auxiliary materials through conventional procedures to make a clinically acceptable of granules.

Embodiment 3

[0039] This example provides a kind of traditional Chinese medicine composition for preventing and treating hypotension in hemodialysis, comprising the following materials by weight: 1 part of total ginseng saponins, 1 part of total lignans from Schisandra chinensis.

[0040] The preparation method of the total ginsenosides and the total lignans of Schisandra chinensis is the same as that in Example 1.

[0041] The preparation method of the pharmaceutical composition for treating hypotension in dialysis comprises the following steps: mixing 1 part of total ginsenosides and 1 part of total lignans of schisandra chinensis from the above raw materials, and adding appropriate amount of auxiliary materials through conventional procedures to make a clinically acceptable of granules.

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Abstract

The invention provides a pharmaceutical composition having a remarkable effect of preventing and treating hypotension in dialysis and being safe and free of toxic and side effects, and provides a preparation method of the pharmaceutical composition. The pharmaceutical composition for preventing and treating the hypotension in the dialysis comprises total ginsenoside and schisandra total lignanoids, wherein the weight ratio of the total ginsenoside to the schisandra total lignanoids is (1-3):(1-5). The preparation method of the pharmaceutical composition for preventing and treating the hypotension in the dialysis provided by the invention is simple and easy to operate, and mild in condition and remarkable, and the composition has a remarkable curative effect. The pharmaceutical compositionfor preventing and treating the hypotension in the dialysis provided by the invention combines modern pharmacological research achievements according to the pathogenesis of hemodialysis hypotension, is rigorous prescription, reasonable in compatibility, has multiple effects of enhancing and improving a central nervous system, a cardiovascular system and an endocrine system substance metabolism andenhancing immune function, can directly excite myocardium, increase the cardiac blood discharge amount and improve microcirculation, and can effectively reduce and relieve the hypotension in the dialysis, improve dialysis quality and improve life quality of hemodialysis patients before being used in hemodialysis.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a pharmaceutical composition for preventing and treating hypotension in dialysis and a preparation method thereof. Background technique [0002] Hemodialysis is the main treatment for patients with end-stage renal disease to maintain life and improve the quality of life. Its basic principle is that blood and dialysate contact through a semi-permeable membrane in a dialyzer, and exchange substances by means of diffusion, osmosis, convection and ultrafiltration. , so that the metabolic waste and excess electrolytes in the blood move to the dialysate, which can replace some functions after renal failure and improve the quality of life of patients with acute and chronic renal failure. [0003] Hemodialysis can significantly prolong the survival of patients with chronic renal failure. However, hemodialysis is not a complete renal replacement therapy. It cannot completely r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/16A61P9/02A61P7/08
CPCA61K9/16A61K36/258A61K36/57A61K36/79A61K2236/33A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61P7/08A61P9/02A61K2300/00
Inventor 邱模炎
Owner 邱模炎
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