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Method for preparing antioxidant-loaded nanometer emulsion by warming phase variation component method

A temperature-raising phase transition and antioxidant technology, which is used in skin care preparations, medical preparations containing active ingredients, cosmetics, etc. Flexibility and low investment effect

Inactive Publication Date: 2020-07-24
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most commonly used method for preparing nanoemulsions in the industry

Method used

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  • Method for preparing antioxidant-loaded nanometer emulsion by warming phase variation component method
  • Method for preparing antioxidant-loaded nanometer emulsion by warming phase variation component method
  • Method for preparing antioxidant-loaded nanometer emulsion by warming phase variation component method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Get caprylic capric triglyceride 1g, mixed surfactant 1g, mixed surfactant is made up of Tween80 and Span80, Tween80:Span80 mass ratio is 6:4, caprylic capric triglyceride and mixed surfactant are at room temperature Mix with magnetic stirring (850 rpm) for 10 min. Then 10 mg of resveratrol was added, and stirring was continued for 30 min at room temperature to obtain a mixed oil phase. Place the mixed oil phase and 8g of ultrapure water in a constant temperature water bath at 50°C to preheat for 10 minutes, then add ultrapure water dropwise to the mixed solution at a rate of 1.5ml / min at a stirring speed of 600 rpm After the dropwise addition, stir for one minute, cool the prepared nanoemulsion to room temperature, and adjust the pH value in the range of 5.0-6.0. The particle size distribution of the prepared nanoemulsion is shown in figure 2 As shown, the cryo-electron microscope image is shown in image 3 shown.

[0034] Implementation result shows, the particle...

Embodiment 2

[0036] Get caprylic capric triglyceride 1g, mixed surfactant 1g, mixed surfactant is made up of Tween80 and Span80, Tween80:Span80 mass ratio is 6:4, caprylic capric triglyceride and mixed surfactant are at room temperature Mix with magnetic stirring (900 rpm) for 10 min. Then 10 mg of resveratrol was added, and stirring was continued for 30 min at room temperature to obtain a mixed oil phase. Place the mixed oil phase and 4g of ultrapure water in a constant temperature water bath at 60°C to preheat for 10 minutes, then add ultrapure water dropwise to the mixed solution at a rate of 1.5ml / min at a stirring speed of 600 rpm After the dropwise addition, stir for one minute, cool the prepared nanoemulsion to room temperature, and adjust the pH value in the range of 5.0-6.0. The particle size distribution of the prepared nanoemulsion is shown in Figure 4 shown.

[0037] Implementation result shows, the particle size distribution figure of the resveratrol nanoemulsion of making...

Embodiment 3

[0039] Get caprylic capric triglyceride 1g, mixed surfactant 1g, mixed surfactant is made up of Tween80 and Span80, Tween80:Span80 mass ratio is 7:3, caprylic capric triglyceride and mixed surfactant are at room temperature Mix with magnetic stirring (950 rpm) for 10 min. Then 100mg of phenylethylresorcinol was added, and stirring was continued for 30min at room temperature to obtain a mixed oil phase. Place the mixed oil phase and 3g of ultrapure water in a constant temperature water bath at 50°C to preheat for 10 minutes, and then add ultrapure water dropwise to the mixed solution at a rate of 1ml / min at a stirring speed of 700 rpm After the dropwise addition is completed, stir for one minute, cool the prepared nanoemulsion to room temperature, and adjust the pH value in the range of 5.0-6.0. The particle size distribution of the prepared nanoemulsion is shown in Figure 5 shown. cryo-electron microscope Image 6 shown.

[0040] Implementation result shows that the part...

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Abstract

The invention discloses a method for preparing antioxidant-loaded nanometer emulsion by a warming phase variation component method. The method comprises the following steps of (1) respectively weighing caprylic capric triglyceride, a mixed surfactant, an antioxidant and ultra pure water in proportion; (2) enabling the mixed surfactant to dissolve in the caprylic capric triglyceride, and adding theantioxidant to form a mixed oil phase; (3) preheating the ultra pure water and the mixed oil phase; (4) dropwise dripping the ultra pure water of the same temperature to the mixed oil phase, and performing continuous stirring to obtain blue opalescence nanometer emulsion; and (5) regulating the pH of prepared nanometer emulsion. A low-energy method is adopted for preparing the nanometer emulsion.The method is safe, simple to operate and low in equipment investment, the prepared nanometer emulsion is uniform in pattern, good in dispersibility, and uniform in liquid drop distribution, and thechemical stability of the antioxidant can be notably improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and cosmetics, and in particular relates to a method for preparing antioxidant-loaded nanoemulsions by a temperature-increasing phase transition component method. Background technique [0002] As the largest emerging market for cosmetics, my country has maintained a rapid growth trend in recent years, especially anti-aging skin care products. The rapid growth of anti-aging skin care products is mainly related to the aging of the skin. There are two main reasons for skin aging: one is the aging of the human body itself, and the other is caused by the external environment, such as ultraviolet radiation and environmental pollution, which will cause free radicals in the body. These free radicals contain unpaired electrons and have extremely high Chemical activity, when accumulated in large quantities in the body, will attack human organs and accelerate the aging of the body. Therefore, free radic...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/37A61K8/34A61K8/06A61Q19/00
CPCA61K8/068A61K8/347A61K8/375A61K8/4993A61K2800/522A61Q19/00
Inventor 吴涛刘文文崔松柱孙德军骆兴伟
Owner SHANDONG UNIV