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Bat-derived coronavirus vaccine for preventing COVID-19

A technology for COVID-19 and coronavirus, applied in the field of bat-derived coronavirus vaccine, to achieve good antibody effect and good homology effect

Pending Publication Date: 2020-07-24
SICHUAN CHENGYU BIOLOGICAL PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, safety remains a major concern with live attenuated vaccines, some of which were eventually replaced by non-replicating or inactivated vaccines

Method used

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  • Bat-derived coronavirus vaccine for preventing COVID-19
  • Bat-derived coronavirus vaccine for preventing COVID-19
  • Bat-derived coronavirus vaccine for preventing COVID-19

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Embodiment Construction

[0029] Below in conjunction with accompanying drawing, the present invention is described in detail.

[0030]In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0031] The origin of SARS-CoV-2 is considered to be natural, from animals. Through the study of the natural reservoir of virus strains, many SARS-like bat coronaviruses have been found, which are 80% similar to SARS-CoV-2 virus. However, the viral nucleic acid sequences of almost all COVID-19 patient samples were 96% similar to a bat (Rhinolophusaffinis) coronavirus Bat / CovRaTG13 collected from Yunnan Province in 2013. The SARS-CoV-2 and Bat / CovRaTG13 strains had 1141 nucleotide variations (subst...

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Abstract

The invention discloses a bat-derived coronavirus vaccine for preventing COVID-19. The bat-derived coronavirus Bat / CovRaTG13 is adopted to produce the vaccine so as to control and prevent the ongoingCOVID-19 pandemic and the future epidemic of the disease. The genetic fingerprint of the Bat / CovRaTG13 is closest to the genetic fingerprint of the 2019 new coronavirus (SARS-CoV-2). Homology of all amino acid sequences not only determines the genetic relationship, but also determines the similarity of biological characteristics, and antigenicity is one of main factors for determining specificityand effectiveness of the vaccine. The vaccine strain comes from a Bat / CovRaTG13 family member, and has sequence homology. The bat coronavirus-derived vaccine can be prepared into three types of vaccines, namely a live vaccine, an inactivated vaccine and / or a recombinant vaccine, through corresponding construction and manufacturing method procedures so as to prevent COVID-19 pandemic.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a bat-derived coronavirus vaccine for preventing COVID-19. Background technique [0002] Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although most cases result in mild symptoms, COVID-19 can rapidly progress to acute respiratory distress syndrome, causing respiratory failure, septic shock, or multiorgan failure. The World Health Organization (WHO) declared the 2019–2020 coronavirus outbreak a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and a COVID-19 pandemic on 11 March 2020. Evidence of local transmission of the disease has been found in many countries in all six WHO regions. The coronavirus pandemic has so far infected more than 1 million people, killed more than 40,000 and led to a global economic recession. [0003] Coronavirus (CoV) is a positive-strand RNA vir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/215C12N7/00A61P31/14
CPCA61K39/12C12N7/00A61P31/14A61K2039/5252C12N2770/20034
Inventor 余力曾蓁曾莲
Owner SICHUAN CHENGYU BIOLOGICAL PROD INC
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