Bat-derived coronavirus vaccine for preventing COVID-19

A technology for COVID-19 and coronavirus, applied in the field of bat-derived coronavirus vaccine, to achieve good antibody effect and good homology effect
CN111437384APending Publication Date: 2020-07-24SICHUAN CHENGYU BIOLOGICAL PROD INC
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN CHENGYU BIOLOGICAL PROD INC
Publication Date
2020-07-24

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Abstract

The invention discloses a bat-derived coronavirus vaccine for preventing COVID-19. The bat-derived coronavirus Bat / CovRaTG13 is adopted to produce the vaccine so as to control and prevent the ongoingCOVID-19 pandemic and the future epidemic of the disease. The genetic fingerprint of the Bat / CovRaTG13 is closest to the genetic fingerprint of the 2019 new coronavirus (SARS-CoV-2). Homology of all amino acid sequences not only determines the genetic relationship, but also determines the similarity of biological characteristics, and antigenicity is one of main factors for determining specificityand effectiveness of the vaccine. The vaccine strain comes from a Bat / CovRaTG13 family member, and has sequence homology. The bat coronavirus-derived vaccine can be prepared into three types of vaccines, namely a live vaccine, an inactivated vaccine and / or a recombinant vaccine, through corresponding construction and manufacturing method procedures so as to prevent COVID-19 pandemic.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to a bat-derived coronavirus vaccine for preventing COVID-19. Background technique

[0002] Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although most cases result in mild symptoms, COVID-19 can rapidly progress to acute respiratory distress syndrome, causing respiratory failure, septic shock, or multiorgan failure. The World Health Organization (WHO) declared the 2019–2020 coronavirus outbreak a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 and a COVID-19 pandemic on 11 March 2020. Evidence of local transmission of the disease has been found in many countries in all six WHO regions. The coronavirus pandemic has so far infected more than 1 million people, killed more than 40,000 and led to a global economic recession.

[0003] Coronavirus (CoV) is a positive-strand RNA vir...

Claims

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