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Application of osteocalcin or propanoic acid to preparation of anti-parkinson's disease drug

A technology for Parkinson's disease and osteocalcin, applied in the field of application of osteocalcin or propionic acid in the preparation of anti-Parkinson's disease drugs, can solve the problem that the progressive loss of dopaminergic neurons cannot be delayed

Pending Publication Date: 2020-07-28
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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Problems solved by technology

Current treatments for Parkinson's disease only partially relieve motor symptoms but do not delay the progressive loss of dopaminergic neurons

Method used

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  • Application of osteocalcin or propanoic acid to preparation of anti-parkinson's disease drug
  • Application of osteocalcin or propanoic acid to preparation of anti-parkinson's disease drug
  • Application of osteocalcin or propanoic acid to preparation of anti-parkinson's disease drug

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Embodiment 1

[0021] 1. Animal experiments 1

[0022] C57BL / 6 male mice (25-30 g) purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. were divided into 5 groups according to the principle of body weight matching (control group, control+4μg / kg OCN group, 6-OHDA group, 6-OHDA+4μg / kg OCN group and 6-OHDA+40μg / kg OCN group) were raised in the SPF environment of the Experimental Animal Center of Minhang Campus, Shanghai Jiao Tong University. After the mice adapted to the new environment for a week, intraperitoneal injection of OCN was started, once a day, and a week later, the PD mouse model was constructed by injecting 6-OHDA into the right striatum, and the OCN intervention was continued until 8 weeks after the intervention. Carry out the following experiment to 5 groups of mice (experimental procedure sees figure 1 A).

[0023] ①Effect of intraperitoneal injection of OCN on the motor function of 6-OHDA-induced PD mice.

[0024] After intraperitoneal injection of ...

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Abstract

The invention relates to an application of osteocalcin or propanoic acid to preparation of an anti-parkinson's disease drug. The invention finds that dyskinesia of a mouse model of a parkinson's disease and damage to dopaminergic neurons can be improved through osteocalcin or propanoic acid intervention on the mouse model of the parkinson's disease; and the finding suggests that the osteocalcin orpropanoic acid has the potential to be a drug to improve the parkinson's disease.

Description

technical field [0001] The invention belongs to the field of anti-Parkinson's disease drugs, in particular to the application of osteocalcin or propionic acid in the preparation of anti-Parkinson's disease drugs. Background technique [0002] Parkinson's disease (PD) is a neurodegenerative disease commonly seen in middle-aged and elderly people, and its main pathological feature is the progressive loss of dopaminergic neurons in the nigrostriatal system. Clinically, the main manifestations are resting tremor, bradykinesia, muscle rigidity and other motor symptoms. Current treatments for Parkinson's disease can only partially alleviate its motor symptoms, but cannot delay the progressive loss of dopaminergic neurons. Evidence shows that intestinal flora and its metabolites short-chain fatty acids (short chain fatty acids, SCFAs) play a very important role in the pathogenesis of PD, so looking for intestinal flora and their metabolites as targets Molecules to improve PD have...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K31/19A61P25/16
CPCA61K38/1709A61K31/19A61P25/16
Inventor 刘建民李胜天侯艳芳单畅赵红燕孙立昊陶蓓
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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