Nano-hydroxyapatite/polydopamine wet-adhesive hemostatic powder for external use and preparation method thereof

Abstract

The invention discloses a nano-hydroxyapatite / polydopamine wet-adhesive hemostatic powder for external use and a preparation method thereof. The hemostatic powder is nano-hydroxyapatite loaded with polydopamine. The preparation method is as follows: adding nanometer hydroxyapatite and dopamine into weak alkaline solution, reacting at room temperature; freeze-drying the product, and preparing nanometer hydroxyapatite / polydopamine needle-shaped composite hemostatic powder. The material has a multifunctional structure of hydroxyapatite and polydopamine, which can be further modified with many substrates. The material can be applied to different forms of hemostasis in different dosage forms, and combined with other medical materials and medical devices, it can be made into emergency life-saving powder, hemostatic hydrogel, self-adhesive dressing, hemostatic antibacterial sponge, etc. Wound healing, pain relief drugs are doped or cross-linked with nano-hydroxyapatite, or these drugs are reacted with polydopamine to prepare new drug delivery carriers and realize the multifunctional integration of hemostatic materials.

Description

technical field [0001] The invention specifically relates to an external nano-hydroxyapatite / polydopamine wet-adhesive hemostatic powder and a preparation method thereof, belonging to the field of biomedical hemostatic materials. Background technique [0002] Uncontrollable bleeding is considered to be the primary cause of death in surgery, war, traffic accidents, etc. The research on hemostatic materials at home and abroad is mostly limited to mild bleeding, and the research on hemostasis of uncontrollable bleeding is still in the blank. At present, the most common solution to uncontrollable bleeding is still to use gauze to compress the bleeding site to achieve hemostasis. Although it can play a certain role in hemostasis, the compression hemostasis method often leads to secondary bleeding after the compression is relieved. Hemostatic materials that can not only adhere to the wound to prevent bleeding, but also form a stable blood clot at the wound to prevent secondary ble...

AI Technical Summary

Problems solved by technology

[0005] Hydroxyapatite is the main component of human bones and teeth. It has good biocompatibility, non-toxicity, non-irritation, no human rejection, no aging, sensitization and carcinogenicity, and can chemically combine with bone tissue. It is widely used as bone substitute materials, plastic and cosmetic surgery materials, dental materials, chromatography purification materials, calcium supplements, etc., but there are no related reports on hemostatic materials.

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